In:
Prenatal Diagnosis, Wiley, Vol. 40, No. 6 ( 2020-05), p. 689-697
Abstract:
To analyze the impact of gestational age (GA) at the time of fetal open spinal dysraphism (OSD) repair through a mini‐hysterotomy on the perinatal outcomes and the infants' ventriculoperitoneal shunt rates. Methods Retrospective study of cases of fetal OSD correction performed from 2014 and 2019. Results One hundred and ninety women underwent fetal surgery for OSD through a mini‐hysterotomy, and 176 (176/190:92.6%) have since delivered. Fetal OSD correction performed earlier in the gestational period, ranging from 19.7 to 26.9 weeks, was associated with lower rates of postnatal ventriculoperitoneal shunting ( P : .049). Earlier fetal surgeries were associated with shorter surgical times ( P : .01), smaller hysterotomy lengths ( P 〈 .001), higher frequencies of hindbrain herniation reversal ( P : .003), and longer latencies from surgery to delivery ( P 〈 .001). Median GA at delivery was 35.3 weeks. Multivariate binary logistic regression showed that both fetal lateral ventricle‐to‐hemisphere ratio (%; P 〈 .001; OR: 1.14 [95% CI: 1.09‐1.21]) and GA at the time of fetal surgery ( P : .016; OR: 1.37 [95% CI: 1.07‐1.77]) were independent predictors of postnatal ventriculoperitoneal shunting. Conclusion Fetuses with OSD who were operated on earlier in the gestational interval, which ranged from 19.7 to 26.9 weeks, were less prone to receiving postnatal ventriculoperitoneal shunts.
Type of Medium:
Online Resource
ISSN:
0197-3851
,
1097-0223
Language:
English
Publisher:
Wiley
Publication Date:
2020
detail.hit.zdb_id:
1491217-X
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