In:
Immunology, Wiley, Vol. 143, No. 2 ( 2014-10), p. 164-173
Abstract:
Dendritic cells ( DC s) are professional antigen‐presenting cells specifically targeted during P lasmodium infection. Upon infection, DC s show impaired antigen presentation and T ‐cell activation abilities. In this study, we aimed to evaluate whether cellular extracts obtained from P lasmodium berghei ‐infected erythrocytes ( P b X ) modulate DC s phenotypically and functionally and the potential therapeutic usage of P b X ‐modulated DC s in the control of experimental autoimmune encephalomyelitis ( EAE , the mouse model for human multiple sclerosis). We found that P b X ‐treated DC s have impaired maturation and stimulated the generation of regulatory T cells when cultured with naive T lymphocytes in vitro . When adoptively transferred to C 57 BL /6 mice the EAE severity was reduced. Disease amelioration correlated with a diminished infiltration of cytokine‐producing T cells in the central nervous system as well as the suppression of encephalitogenic T cells. Our study shows that extracts obtained from P . berghei ‐infected erythrocytes modulate DC s towards an immunosuppressive phenotype. In addition, the adoptive transfer of P b X ‐modulated DC s was able to ameliorate EAE development through the suppression of specific cellular immune responses towards neuro‐antigens. To our knowledge, this is the first study to present evidence that DC s treated with P . berghei extracts are able to control autoimmune neuroinflammation.
Type of Medium:
Online Resource
ISSN:
0019-2805
,
1365-2567
DOI:
10.1111/imm.2014.143.issue-2
Language:
English
Publisher:
Wiley
Publication Date:
2014
detail.hit.zdb_id:
2006481-0
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