In:
The Journal of Immunology, The American Association of Immunologists, Vol. 202, No. 1_Supplement ( 2019-05-01), p. 182.85-182.85
Abstract:
Antibodies show excellent stability in blood; therefore, they can be utilized for screening of convenient blood-based markers of Alzheimer’s disease dementia (AD). This study used unbiased microarrays comprising 29,240 random peptides to screen for AD-specific antibodies. The results showed that 1) antibodies are specifically regulated in AD and certain combinations show high area under the receiver operating characteristic curve values (0.862–0.961); 2) AD-specific IgG antibodies arise from established IgM antibody-secreting cells; and 3) analysis of proteins targeted by differentially regulated antibodies identified AD-related signaling pathways. Thus, plasma antibodies targeting specific epitopes are regulated in AD; these epitopes may facilitate biomarker development.
Type of Medium:
Online Resource
ISSN:
0022-1767
,
1550-6606
DOI:
10.4049/jimmunol.202.Supp.182.85
Language:
English
Publisher:
The American Association of Immunologists
Publication Date:
2019
detail.hit.zdb_id:
1475085-5
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