GLORIA

GEOMAR Library Ocean Research Information Access

X

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Online Resource
    Online Resource
    Subcortical Brain Volume, Regional Cortical Thickness, and Cortical Surface Area Across Disorders: Findings From the ENIGMA ADHD, ASD, and OCD Working Groups
    American Psychiatric Association Publishing ; 2020
    In:  American Journal of Psychiatry Vol. 177, No. 9 ( 2020-09-01), p. 834-843
    Details
    In: American Journal of Psychiatry, American Psychiatric Association Publishing, Vol. 177, No. 9 ( 2020-09-01), p. 834-843
    Type of Medium: Online Resource
    ISSN: 0002-953X , 1535-7228
    URL: Article
    DOI: 10.1176/appi.ajp.2020.19030331
    RVK:
    XA 10000
    Language: English
    Publisher: American Psychiatric Association Publishing
    Publication Date: 2020
    detail.hit.zdb_id: 1500554-9
    SSG: 5,2
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 2
    Online Resource
    Online Resource
    Impact of Abdominal Follow-Up Sonography in Trauma Patients Without Abdominal Parenchymal Organ Lesion or Free Intraabdominal Fluid in Whole-Body Computed Tomography
    Georg Thieme Verlag KG ; 2017
    In:  RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren Vol. 189, No. 02 ( 2017-1-31), p. 128-136
    Details
    In: RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren, Georg Thieme Verlag KG, Vol. 189, No. 02 ( 2017-1-31), p. 128-136
    Type of Medium: Online Resource
    ISSN: 1438-9029 , 1438-9010
    URL: Article
    DOI: 10.1055/s-0042-120844
    RVK:
    XA 10000
    Language: German
    Publisher: Georg Thieme Verlag KG
    Publication Date: 2017
    detail.hit.zdb_id: 2031079-1
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 3
    Online Resource
    Online Resource
    IER-SICH Nomogram to Predict Symptomatic Intracerebral Hemorrhage After Thrombectomy for Stroke
    Ovid Technologies (Wolters Kluwer Health) ; 2019
    In:  Stroke Vol. 50, No. 4 ( 2019-04), p. 909-916
    Details
    In: Stroke, Ovid Technologies (Wolters Kluwer Health), Vol. 50, No. 4 ( 2019-04), p. 909-916
    Abstract: As a reliable scoring system to detect the risk of symptomatic intracerebral hemorrhage after thrombectomy for ischemic stroke is not yet available, we developed a nomogram for predicting symptomatic intracerebral hemorrhage in patients with large vessel occlusion in the anterior circulation who received bridging of thrombectomy with intravenous thrombolysis (training set), and to validate the model by using a cohort of patients treated with direct thrombectomy (test set). Methods— We conducted a cohort study on prospectively collected data from 3714 patients enrolled in the IER (Italian Registry of Endovascular Stroke Treatment in Acute Stroke). Symptomatic intracerebral hemorrhage was defined as any type of intracerebral hemorrhage with increase of ≥4 National Institutes of Health Stroke Scale score points from baseline ≤24 hours or death. Based on multivariate logistic models, the nomogram was generated. We assessed the discriminative performance by using the area under the receiver operating characteristic curve. Results— National Institutes of Health Stroke Scale score, onset-to-end procedure time, age, unsuccessful recanalization, and Careggi collateral score composed the IER-SICH nomogram. After removing Careggi collateral score from the first model, a second model including Alberta Stroke Program Early CT Score was developed. The area under the receiver operating characteristic curve of the IER-SICH nomogram was 0.778 in the training set (n=492) and 0.709 in the test set (n=399). The area under the receiver operating characteristic curve of the second model was 0.733 in the training set (n=988) and 0.685 in the test set (n=779). Conclusions— The IER-SICH nomogram is the first model developed and validated for predicting symptomatic intracerebral hemorrhage after thrombectomy. It may provide indications on early identification of patients for more or less postprocedural intensive management.
    Type of Medium: Online Resource
    ISSN: 0039-2499 , 1524-4628
    URL: Article
    DOI: 10.1161/STROKEAHA.118.023316
    RVK:
    XA 10000
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2019
    detail.hit.zdb_id: 1467823-8
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 4
    Online Resource
    Online Resource
    Abstract 2358: MUC13 mucin augments pancreatic tumorigenesis
    American Association for Cancer Research (AACR) ; 2010
    In:  Cancer Research Vol. 70, No. 8_Supplement ( 2010-04-15), p. 2358-2358
    Details
    In: Cancer Research, American Association for Cancer Research (AACR), Vol. 70, No. 8_Supplement ( 2010-04-15), p. 2358-2358
    Abstract: Pancreatic cancer is one of the most lethal malignancies with extremely poor prognosis. The high death rate of pancreatic cancer is attributed to a lack of reliable methods of early diagnosis and underlying molecular mechanisms associated with aggressive pathogenesis. MUC13, a newly identified transmembrane mucin, is known to be aberrantly expressed in ovarian, gastric and colon cancer. However, the expression and functions of MUC13 in pancreatic cancer are unknown. Herein, we have investigated the expression and functions of MUC13 mucin, in pancreatic cancer to determine its potential for early cancer diagnosis and its role in pancreatic cancer pathogenesis. The expression profile of MUC13 in pancreatic cancer was investigated using a recently generated monoclonal antibody (MAb, clone PPZ0020) and pancreatic tissue microarrays. The expression of MUC13 was significantly (p & lt;0.005) higher in cancer samples compared to the normal/non-neoplastic pancreatic tissues. For the functional analyses, a full length MUC13 gene cloned in pcDNA3.1 was expressed in MUC13 null pancreatic cancer cell lines, MiaPaca and Panc1. The exogenous MUC13 expression induced morphological changes, including scattering of cells. These changes were abrogated through c-jun NH2-terminal kinase (JNK) chemical inhibitor (SP600125) or JNK2 siRNA. Additionally, a marked reduction in cell-cell adhesion and significant (p & lt;0.05) increases in cell motility, invasion, proliferation, clonogenicity and tumorigenesis in a xenograft mouse model system were observed upon exogenous MUC13 expression. These cellular characteristics were correlated with the up-regulation of HER2, p21-activated kinase1 (PAK1), extracellular signal-regulated kinase (ERK) and S100A4 (metastasin) and suppression of p53. Inhibition of MUC13 expression by MUC13 siRNA or shRNA resulted in suppression of tumorigenic characteristics in HPAFII pancreatic cancer cells. These results, for the first time, suggest that MUC13 expression augments pancreatic cancer progression and has potential as a diagnostic and/or therapeutic target. Note: This abstract was not presented at the AACR 101st Annual Meeting 2010 because the presenter was unable to attend. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 2358.
    Type of Medium: Online Resource
    ISSN: 0008-5472 , 1538-7445
    URL: Article
    DOI: 10.1158/1538-7445.AM10-2358
    RVK:
    XA 36000
    RVK:
    XA 10000
    Language: English
    Publisher: American Association for Cancer Research (AACR)
    Publication Date: 2010
    detail.hit.zdb_id: 2036785-5
    detail.hit.zdb_id: 1432-1
    detail.hit.zdb_id: 410466-3
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 5
    Online Resource
    Online Resource
    Expression and Functions of Transmembrane Mucin MUC13 in Ovarian Cancer
    American Association for Cancer Research (AACR) ; 2009
    In:  Cancer Research Vol. 69, No. 3 ( 2009-02-01), p. 765-774
    Details
    In: Cancer Research, American Association for Cancer Research (AACR), Vol. 69, No. 3 ( 2009-02-01), p. 765-774
    Abstract: MUC13, a transmembrane mucin, is normally expressed in gastrointestinal and airway epithelium. Its aberrant expression has been correlated with gastric colon and cancer. However, the expression and functions of MUC13 in ovarian cancer are unknown. In the present study, the expression profile and functions of MUC13 were analyzed to elucidate its potential role in ovarian cancer diagnosis and pathogenesis. A recently generated monoclonal antibody (clone PPZ0020) was used to determine the expression profile of MUC13 by immunohistochemistry using ovarian cancer tissue microarrays and 56 additional epithelial ovarian cancer (EOC) samples. The expression of MUC13 was significantly (P & lt; 0.005) higher in cancer samples compared with the normal ovary/benign tissues. Among all ovarian cancer types, MUC13 expression was specifically present in EOC. For the functional analyses, a full-length MUC13 gene cloned in pcDNA3.1 was expressed in a MUC13 null ovarian cancer cell line, SKOV-3. Here, we show that the exogenous MUC13 expression induced morphologic changes, including scattering of cells. These changes were abrogated through c-Jun NH2 kinase (JNK) chemical inhibitor (SP600125) or JNK2 siRNA. Additionally, a marked reduction in cell-cell adhesion and significant (P & lt; 0.05) increases in cell motility, proliferation, and tumorigenesis in a xenograft mouse model system were observed upon exogenous MUC13 expression. These cellular characteristics were correlated with up-regulation of HER2, p21-activated kinase 1, and p38 protein expression. Our findings show the aberrant expression of MUC13 in ovarian cancer and that its expression alters the cellular characteristics of SKOV-3 cells. This implies a significant role of MUC13 in ovarian cancer. [Cancer Res 2009;69(3):765–74]
    Type of Medium: Online Resource
    ISSN: 0008-5472 , 1538-7445
    URL: Article
    DOI: 10.1158/0008-5472.CAN-08-0587
    RVK:
    XA 36000
    RVK:
    XA 10000
    Language: English
    Publisher: American Association for Cancer Research (AACR)
    Publication Date: 2009
    detail.hit.zdb_id: 2036785-5
    detail.hit.zdb_id: 1432-1
    detail.hit.zdb_id: 410466-3
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 6
    Online Resource
    Online Resource
    Abstract 5325: Role of MUC13 in colon cancer progression
    American Association for Cancer Research (AACR) ; 2012
    In:  Cancer Research Vol. 72, No. 8_Supplement ( 2012-04-15), p. 5325-5325
    Details
    In: Cancer Research, American Association for Cancer Research (AACR), Vol. 72, No. 8_Supplement ( 2012-04-15), p. 5325-5325
    Abstract: Colon cancer is the third most commonly diagnosed and second leading cause of cancer related deaths in the United States. Mucin 13 (MUC13), a high molecular weight glycoprotein, is a recently identified transmembrane mucin. While MUC13 is known to be over expressed in gastric and ovarian cancers, limited information about MUC13 is available in colon cancer progression. Therefore, our aim is to investigate the expression profile, potential role and possible regulatory pathways of MUC13 in colon cancer progression. We performed immunohistochemical analysis using MUC13 monoclonal antibody (ppz0020) to determine expression profile and aberrant localization of MUC13 in colon cancer cells. Our results indicate that MUC13 is over expressed in colon cancer predominantly at the apical surface. MUC13 is also aberrantly localized (cytoplasmic and nuclear) in metastasized colon cancer and in liver metastasis. We also correlated MUC13 expression levels with clinico-pathological parameters of patients. Increased MUC13 expression correlated with increased tumor size and poorly differentiated colon cancer. To determine the functional roles of MUC13 we generated stable MUC13 over expressing and MUC13 knock down cells and performed functional assays. Our results demonstrate that MUC13 increased cell proliferation, colony formation, cell migration and cell invasion characteristics of colon cancer cells. In order to investigate proteins that are affected by MUC13, we performed immunoblot assays. Immunoblot analysis revealed that MUC13 increased expression of several proteins that are associated with colon cancer progression and metastasis such as Bmi-1(B cell specific lymphoma moloney murine leukemia integration site-1), TERT (telomerase reverse transcriptase), Shh (sonic hedgehog) and GATA1 (GATA binding protein 1). We also examined potential signaling pathways that may be associated with MUC13 colon carcinogenesis. We found that MUC13 increased expression of mitogen activated kinase (MAPK) pathway members such as ERK-1 and phospho ERK-1. In order to determine potential transcriptions factors that may regulate MUC13 expression, we screened expression of various transcription factors by real time PCR. Significantly high expression of STAT5B (signal transducers and activators of transcription factor 5B) was detected in cell lines expressing endogenously high levels of MUC13. In order to confirm transcription factor STAT5B binding sites in the MUC13 promotor, we performed chromatin immunoprecipitation (CHIP). CHIP analysis revealed that STAT5B binds to the promoter of MUC13. In summary, our study revealed that MUC13 is over expressed in colon cancer and aberrantly localized in metastasis. Over expression of MUC13 increases cell proliferation, colony formation, cell migration, cell invasion and expression of metastasis associated proteins partly via MAPK pathway. MUC13 expression may be regulated through binding of STAT5B to the MUC13 promoter. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 5325. doi:1538-7445.AM2012-5325
    Type of Medium: Online Resource
    ISSN: 0008-5472 , 1538-7445
    URL: Article
    DOI: 10.1158/1538-7445.AM2012-5325
    RVK:
    XA 36000
    RVK:
    XA 10000
    Language: English
    Publisher: American Association for Cancer Research (AACR)
    Publication Date: 2012
    detail.hit.zdb_id: 2036785-5
    detail.hit.zdb_id: 1432-1
    detail.hit.zdb_id: 410466-3
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 7
    Online Resource
    Online Resource
    Abstract 1481: MUC13 expression enhances colon cancer progression
    American Association for Cancer Research (AACR) ; 2011
    In:  Cancer Research Vol. 71, No. 8_Supplement ( 2011-04-15), p. 1481-1481
    Details
    In: Cancer Research, American Association for Cancer Research (AACR), Vol. 71, No. 8_Supplement ( 2011-04-15), p. 1481-1481
    Abstract: Background: Mucin, a family of high molecular weight glycoprotein has been implicated in a variety of cancers. MUC13 is a newly identified transmembrane mucin which has shown deregulated expression in gastric and ovarian cancers. However, limited information is available about the role of MUC13 in colon cancer progression. The present study investigated the expression profile, clinical relevance and functional significance of MUC13 expression in colon cancer progression. Materials and Methods: The MUC13 expression profile was determined by immunohistochemical (IHC) analysis using a novel MUC13 monoclonal antibody (PPZ0020) on a panel of colon cancer tissue microarrays containing non-malignant, colon cancer and liver metastasis tissue samples. Colon cancer cell lines which showed faint (SW480) and high (SW620) MUC13 expression were selected for over-expression and knockdown experiments, respectively, to determine the functional role of MUC13 in colon cancer progression. Functional studies, such as cell proliferation, colony formation, cell migration and cell invasion assays were performed in stable clones. The levels of Sonic hedehog (Shh), B cell moloney murine leukemia virus integration site 1 (Bmi-1) and Matrix metalloproteinase 1 (MMP1) were determined using real time PCR, Western blot and flow cytometry analyses. Results: Differential expression and sub-cellular localization of MUC13 was observed in cancerous and non-malignant tissues. MUC13 IHC analysis showed significantly higher membranous and cytoplasmic MUC13 expression in colon cancer and liver metastasis tissues compared to non-malignant tissue samples. Interestingly, liver metastasis tissue samples showed significantly higher nuclear MUC13 expression in addition to high membranous and cytoplasmic expression. The over-expression of MUC13 enhanced cell proliferation, colony formation, cell migration and cell invasion. In contrast, knockdown of MUC13 resulted in reduced cell proliferation, colony formation, cell migration and cell invasion. Additionally, over-expression of MUC13 increased the expression level of metastatic associated proteins such as Shh, Bmi-1 and MMP1 while knockdown of MUC13 decreased the expression level of these proteins. Conclusions: The present study suggests two important outcomes pertaining to MUC13 in colon cancer: (1) The aberrant expression of MUC13 could serve as a potential diagnostic/prognostic molecular tool for clinical use, and (2) MUC13 over-expression may enhance colon cancer carcinogenesis via modulation of metastatic proteins Bmi-1, Shh and MMP1. These data suggest a potential role of MUC13 in colon cancer progression and metastasis. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 1481. doi:10.1158/1538-7445.AM2011-1481
    Type of Medium: Online Resource
    ISSN: 0008-5472 , 1538-7445
    URL: Article
    DOI: 10.1158/1538-7445.AM2011-1481
    RVK:
    XA 36000
    RVK:
    XA 10000
    Language: English
    Publisher: American Association for Cancer Research (AACR)
    Publication Date: 2011
    detail.hit.zdb_id: 2036785-5
    detail.hit.zdb_id: 1432-1
    detail.hit.zdb_id: 410466-3
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 8
    Online Resource
    Online Resource
    Ventral tegmental area dysfunction affects decision-making in patients with myotonic dystrophy type-1
    Elsevier BV ; 2020
    In:  Cortex Vol. 128 ( 2020-07), p. 192-202
    Details
    In: Cortex, Elsevier BV, Vol. 128 ( 2020-07), p. 192-202
    Type of Medium: Online Resource
    ISSN: 0010-9452
    URL: Article
    DOI: 10.1016/j.cortex.2020.03.022
    RVK:
    XA 10000
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2020
    detail.hit.zdb_id: 2080335-7
    SSG: 12
    SSG: 5,2
    SSG: 5,21
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 9
    Online Resource
    Online Resource
    HPV E2, E4, E5 drive alternative carcinogenic pathways in HPV positive cancers
    Springer Science and Business Media LLC ; 2020
    In:  Oncogene Vol. 39, No. 40 ( 2020-10-01), p. 6327-6339
    Details
    In: Oncogene, Springer Science and Business Media LLC, Vol. 39, No. 40 ( 2020-10-01), p. 6327-6339
    Abstract: The dominant paradigm for HPV carcinogenesis includes integration into the host genome followed by expression of E6 and E7 (E6/E7). We explored an alternative carcinogenic pathway characterized by episomal E2, E4, and E5 (E2/E4/E5) expression. Half of HPV positive cervical and pharyngeal cancers comprised a subtype with increase in expression of E2/E4/E5, as well as association with lack of integration into the host genome. Models of the E2/E4/E5 carcinogenesis show p53 dependent enhanced proliferation in vitro, as well as increased susceptibility to induction of cancer in vivo. Whole genomic expression analysis of the E2/E4/E5 pharyngeal cancer subtype is defined by activation of the fibroblast growth factor receptor (FGFR) pathway and this subtype is susceptible to combination FGFR and mTOR inhibition, with implications for targeted therapy.
    Type of Medium: Online Resource
    ISSN: 0950-9232 , 1476-5594
    URL: Article
    DOI: 10.1038/s41388-020-01431-8
    RVK:
    XA 10000
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2020
    detail.hit.zdb_id: 2008404-3
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...