In:
The British Journal of Radiology, British Institute of Radiology, Vol. 95, No. 1135 ( 2022-07-01)
Abstract:
Parkinson’s disease is a neurodegenerative disorder caused by neuronal cell loss in the substantia nigra pars compacta (SNpc). We aimed to perform atlas-based relaxometry using an anatomical SNpc atlas and obtain baseline values of SNpc regions in healthy volunteers. Methods: Neuromelanin (NM)-sensitive imaging of the midbrain and whole-brain 3D T 1 weighted images of 27 healthy volunteers (20 males; aged 36.3 ± 11.5 years) were obtained. An anatomical SNpc atlas was created using NM-sensitive images in standard space, and divided into medial (MG), dorsal (DG), and ventrolateral (VG) groups. Proton density (PD), T 1 , and T 2 values in these regions were obtained using quantitative MRI. The relationships between PD, T 1 , and T 2 values in each SNpc region and age were evaluated. Results: The VG PD value was significantly higher than the MG and DG values. MG, DG, and VG T 1 values were significantly different, whereas the T 2 value of the MG was significantly lower than the DG and VG values. Moreover, a significant negative correlation between PD and T 1 values of the MG and age was observed. Conclusion: The PD, T 1 , and T 2 values of the SNpc regions measured in standard space using an anatomical atlas can be used as baseline values. PD and T 1 values of the SNpc regions may be associated with NM concentrations. Advances in knowledge: An anatomical SNpc atlas was created using NM-sensitive MRI and can be used for the quantitative evaluation of subsegments of the SNpc in standard space.
Type of Medium:
Online Resource
ISSN:
0007-1285
,
1748-880X
DOI:
10.1259/bjr.20210572
Language:
English
Publisher:
British Institute of Radiology
Publication Date:
2022
detail.hit.zdb_id:
1468548-6
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