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  • 1
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    Online Resource
    Hypercholesterolemia Impairs a Detoxification Mechanism Against Peroxynitrite and Renders the Vascular Tissue More Susceptible to Oxidative Injury
    Ovid Technologies (Wolters Kluwer Health) ; 1997
    In:  Circulation Research Vol. 80, No. 6 ( 1997-06), p. 894-901
    Details
    In: Circulation Research, Ovid Technologies (Wolters Kluwer Health), Vol. 80, No. 6 ( 1997-06), p. 894-901
    Abstract: Abstract Previous studies have shown that glutathione (GSH) plays a central role in the protection against peroxynitrite (ONOO − ) toxicity. The present study evaluated the changes of the GSH cytoprotective system against ONOO − in hypercholesterolemia and determined the effects of carvedilol, a β-blocker with free radical–scavenging activity, on these hypercholesterol-induced changes. New Zealand White rabbits were fed either a normal diet, a high-cholesterol diet, or a high-cholesterol diet supplemented with either carvedilol or propranolol. Eight weeks later, the rabbits were killed, and the thoracic aortas were isolated. Total GSH content of aortic tissue, vasorelaxation response of aortic rings to exogenous ONOO − , · NO regeneration from ONOO − by aortic homogenate, and ONOO − -induced aortic tissue injury were examined. Hypercholesterolemia decreased tissue GSH content (0.52±0.08 versus 0.86±0.04 μmol/g in control, P 〈 .01), attenuated the vasorelaxation response to ONOO − (40±4.1% versus 76±3.2%, P 〈 .01), reduced · NO regeneration from ONOO − (387±40 versus 662±51 pmol, P 〈 .01), and potentiated ONOO − -induced vascular tissue injury (37±4.4% versus 14±2.6% of increase in lactate dehydrogenase release after 3-morpholinosydnonimine exposure, P 〈 .01). Treatment of the hypercholesterolemic rabbits with carvedilol, but not propranolol, significantly preserved tissue GSH content (0.79±0.05 μmol/g, P 〈 .01 versus nontreated hypercholesterolemic rabbits), restored the vasorelaxation to ONOO − (61±2%, P 〈 .01), increased · NO regeneration from ONOO − (583±39 pmol, P 〈 .01), and attenuated ONOO − -induced tissue injury (19±1.8%, P 〈 .01). These results suggest that hypercholesterolemia impairs the GSH-mediated detoxification mechanism against ONOO − and renders the vascular tissue more susceptible to oxidative injury. Carvedilol, a novel vasodilating β-blocker with antioxidant activity, significantly preserved this self-defense system and protected tissue from oxidant injury.
    Type of Medium: Online Resource
    ISSN: 0009-7330 , 1524-4571
    URL: Article
    DOI: 10.1161/01.RES.80.6.894
    RVK:
    XA 10000
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 1997
    detail.hit.zdb_id: 1467838-X
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  • 2
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    Introgression, admixture, and selection facilitate genetic adaptation to high-altitude environments in cattle
    Elsevier BV ; 2021
    In:  Genomics Vol. 113, No. 3 ( 2021-05), p. 1491-1503
    Details
    In: Genomics, Elsevier BV, Vol. 113, No. 3 ( 2021-05), p. 1491-1503
    Type of Medium: Online Resource
    ISSN: 0888-7543
    URL: Article
    DOI: 10.1016/j.ygeno.2021.03.023
    RVK:
    XA 10000
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2021
    detail.hit.zdb_id: 1468023-3
    SSG: 12
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  • 3
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    MicroRNA‐30a Promotes B Cell Hyperactivity in Patients With Systemic Lupus Erythematosus by Direct Interaction With Lyn
    Wiley ; 2013
    In:  Arthritis & Rheumatism Vol. 65, No. 6 ( 2013-06), p. 1603-1611
    Details
    In: Arthritis & Rheumatism, Wiley, Vol. 65, No. 6 ( 2013-06), p. 1603-1611
    Abstract: To investigate why the level of Lyn is significantly decreased in B cells from a majority of patients with systemic lupus erythematosus (SLE) and to determine the role of microRNA‐30a (miR‐30a) in SLE B cell hyperactivity. Methods Luciferase reporter gene assays were performed to identify the interaction between miR‐30a and the 3′‐untranslated region (3′‐UTR) of Lyn. Levels of miR‐30a in B cells were determined by TaqMan quantitative polymerase chain reaction (qPCR), Lyn messenger RNA levels were tested with real‐time qPCR, and protein levels of Lyn were determined using Western blotting. The quantity of IgG was determined by enzyme‐linked immunosorbent assay. The proliferation of B cells was measured using 3 H‐thymidine incorporation. Results In B cell lines, miR‐30a, but not miR‐30b, miR‐30c, miR‐30d, or miR‐30e, could specifically bind the 3′‐UTR of Lyn, and overexpression of miR‐30a inhibited the levels of Lyn. The level of miR‐30a in B cells was significantly higher in SLE patients compared to healthy donors. The level of miR‐30a was negatively associated with the level of Lyn in B cells. Overexpression of miR‐30a was found to promote B cell proliferation and the production of IgG antibodies. The effect of miR‐30a could be abrogated by inducing overexpression of Lyn in B cells. Conclusion These results reveal that elevated expression of miR‐30a is responsible for the reduction in levels of Lyn in B cells from patients with SLE, suggesting that miR‐30a plays an important role in B cell hyperactivity.
    Type of Medium: Online Resource
    ISSN: 0004-3591 , 1529-0131
    URL: Issue
    URL: Article
    DOI: 10.1002/art.v65.6
    DOI: 10.1002/art.37912
    RVK:
    XA 10000
    RVK:
    XA 30325
    Language: English
    Publisher: Wiley
    Publication Date: 2013
    detail.hit.zdb_id: 2014367-9
    detail.hit.zdb_id: 2754614-7
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  • 4
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    Platelet infiltration predicts survival in postsurgical colorectal cancer patients
    Wiley ; 2022
    In:  International Journal of Cancer Vol. 150, No. 3 ( 2022-02), p. 509-520
    Details
    In: International Journal of Cancer, Wiley, Vol. 150, No. 3 ( 2022-02), p. 509-520
    Abstract: What's new? Recent research has increasingly linked the tumor microenvironment with tumor progression and metastasis. Platelets are known to infiltrate and interact with the tumor microenvironment. In this study, the authors found that platelet infiltration correlated with poor prognosis in several types of cancer. They then validated their analysis in tumors from colorectal cancer (CRC) patients. Platelet infiltration was associated with decreased postsurgical survival, and this measure was more accurate than TMN staging alone. Platelet infiltration might therefore offer a useful prognostic biomarker for postsurgical CRC patients.
    Type of Medium: Online Resource
    ISSN: 0020-7136 , 1097-0215
    URL: Issue
    URL: Article
    DOI: 10.1002/ijc.v150.3
    DOI: 10.1002/ijc.33816
    RVK:
    XA 10000
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 218257-9
    detail.hit.zdb_id: 1474822-8
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  • 5
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    Online Resource
    EGFR‐TKIs plus local therapy demonstrated survival benefit than EGFR‐TKIs alone in EGFR‐mutant NSCLC patients with oligometastatic or oligoprogressive liver metastases
    Wiley ; 2019
    In:  International Journal of Cancer Vol. 144, No. 10 ( 2019-05-15), p. 2605-2612
    Details
    In: International Journal of Cancer, Wiley, Vol. 144, No. 10 ( 2019-05-15), p. 2605-2612
    Abstract: What's new? Patients with non‐small cell lung cancer (NSCLC) who develop liver metastases frequently suffer poor prognosis, despite treatment with otherwise highly effective epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs). In the effort to overcome this problem, the authors of this study examined patient outcomes following combined treatment with EGFR‐TKIs and local therapy. A significant improvement in progression‐free survival and overall survival was detected following administration of combined therapy in EGFR‐mutant NSCLC patients with oligometastatic or oligoprogressive liver metastases. The findings suggest that combined local therapy and EGFR‐TKIs could help improve patient outcome in EGFR‐mutant NSCLC with liver metastasis.
    Type of Medium: Online Resource
    ISSN: 0020-7136 , 1097-0215
    URL: Issue
    URL: Article
    DOI: 10.1002/ijc.v144.10
    DOI: 10.1002/ijc.31962
    RVK:
    XA 10000
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 218257-9
    detail.hit.zdb_id: 1474822-8
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  • 6
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    GW25-e3362 Evaluation of right ventricular global and regional volume and systolic function in TOF children by RT-3DE
    Elsevier BV ; 2014
    In:  Journal of the American College of Cardiology Vol. 64, No. 16 ( 2014-10), p. C191-
    Details
    In: Journal of the American College of Cardiology, Elsevier BV, Vol. 64, No. 16 ( 2014-10), p. C191-
    Type of Medium: Online Resource
    ISSN: 0735-1097
    URL: Article
    DOI: 10.1016/j.jacc.2014.06.884
    RVK:
    XA 17760
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2014
    detail.hit.zdb_id: 1468327-1
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  • 7
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    Apatinib enhanced anti-tumor activity of cisplatin on triple-negative breast cancer through inhibition of VEGFR-2
    Elsevier BV ; 2019
    In:  Pathology - Research and Practice Vol. 215, No. 7 ( 2019-07), p. 152422-
    Details
    In: Pathology - Research and Practice, Elsevier BV, Vol. 215, No. 7 ( 2019-07), p. 152422-
    Type of Medium: Online Resource
    ISSN: 0344-0338
    URL: Article
    DOI: 10.1016/j.prp.2019.04.014
    RVK:
    XA 10000
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2019
    detail.hit.zdb_id: 2039756-2
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  • 8
    Online Resource
    Online Resource
    Immunogenomic classification of gastric cancer based on the tumor microenvironments expression of PD-L1 and CD8+ T-cell infiltration.
    American Society of Clinical Oncology (ASCO) ; 2020
    In:  Journal of Clinical Oncology Vol. 38, No. 15_suppl ( 2020-05-20), p. e16578-e16578
    Details
    In: Journal of Clinical Oncology, American Society of Clinical Oncology (ASCO), Vol. 38, No. 15_suppl ( 2020-05-20), p. e16578-e16578
    Abstract: e16578 Background: Previous data has shown that a positive response to immunotherapy usually relies on active interactions between tumor cells and immunomodulators inside the tumor microenvironment (TME). The aim of this study was to classify gastric cancer (GC) subsets based on the TME immune status according to the expression of PD-L1 and infiltration of CD8+ T cells. Methods: One hundred and eighty-six tumor tissue from gastric cancer patients with a curative D2 gastrectomy were examined for evaluating PD-L1 and CD8+ T cells status using histopathologic analysis. The molecular characteristics of 289 GC samples in TCGA network were further analyzed to distinguish the genetic features of four immune subtypes depending on the presence of PD-L1/CD8+T cell. Results: GC samples were categorized into four types, type I (CD8+/PD-L1+, 60.3%), II (CD8-/PD-L1-, 11.8%), III (CD8-/PD-L1+, 0%), and IV (CD8+/PD-L1-, 27.9%), basing on PD-L1/CD8 expression. The PD-L1 expressing level was geographically associated with the intensity of CD8+ T cell infiltration which was significantly associated with disease-free survival (DFS) and overall survival (OS) (p = 0.003 and p = 0.006). Distinct patterns of genetic profile were described in four types of GC from TCGA database. Type I and III which PD-L1 were overly expressed had comparatively higher MSI and TMB, with EBV mainly enriched in Type I, whereas CIN was more likely to occur in PD-L1 aberrant types II and IV. SNV analysis illustrated higher gene mutations in oncogenes (PIK3CA and ERBB2), and in DNA damage repair related pathway, such as PRKDC, ATM, and SWI/SNF complexes (e.g. ARID1A) in Type I. However, TP53 mutations tend to enrich in Type II and IV. Similar results were obtained by transcriptome analysis. Conclusions: The genetic features of four immune subtypes proof that PD-L1 and CD8+ T cells status are reasonable immunogenomic classification of gastric cancer. SNV analysis prompts a potential mechanism for effectiveness of immunotherapy in Type I patients. Overall, the results may be useful for the development of clinical treatments for the blockade of immune checkpoints.
    Type of Medium: Online Resource
    ISSN: 0732-183X , 1527-7755
    URL: Article
    DOI: 10.1200/JCO.2020.38.15_suppl.e16578
    RVK:
    XA 52760
    RVK:
    XA 10000
    Language: English
    Publisher: American Society of Clinical Oncology (ASCO)
    Publication Date: 2020
    detail.hit.zdb_id: 2005181-5
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  • 9
    Online Resource
    Online Resource
    Nasal-Type NK/T Cell Lymphoma: Clinical Features, Immunophenotype and Treatment Outcome
    American Society of Hematology ; 2008
    In:  Blood Vol. 112, No. 11 ( 2008-11-16), p. 5296-5296
    Details
    In: Blood, American Society of Hematology, Vol. 112, No. 11 ( 2008-11-16), p. 5296-5296
    Abstract: The clinical characteristics and prognosis remain unclear for nasal-type NK/T-cell lymphoma. The aim of this study is to determine the clinical features and outcome. 26 patients diagnosed as nasal-type NK/T cell lymphoma were included in the analysis. Immunophenotype was analyzed by immunohistochemical staining for LCA, CD79α, CD20, CD56, CD3, CD45RO, All the cases of nasal NK/T cell lymphoma were LCA, The positivity rates of CD45RO and CD56 were 89.8%, and 66%, respectively. Tumor cells didn’t express antigens of B and histiocyte, According to Ann Arbor system, 2, 7, 12, and 5 patients had stage I, II, III, and IV. 24 patients received combined chemotherapy(CHOP plus Ara-c) and radiotherapy, and 2 patients received chemotherapy alone. The disease is characterized by predominant young males, a propensity for nodal involvement, frequent stage II–III diseases, low frequency of elevated LDH, low-risk international prognostic index (IPI), high sensitivity to radiotherapy, and intermediate sensitivity to chemotherapy. The 3-year overall survival and progression-free survival for all patients were 88% and 71%, respectively The age, B symptoms, stage, and IPI were important prognostic factors. Combined chemotherapy(CHOP plus Ara-c) and radiotherapy tended to improve the survival for patients with stage and II or III diseases. The distant extranodal dissemination were the primary failure patterns. nasal-type NK/T-cell lymphoma appears to have distinct clinical characteristics and favorable outcomes.
    Type of Medium: Online Resource
    ISSN: 0006-4971 , 1528-0020
    URL: Article
    DOI: 10.1182/blood.V112.11.5296.5296
    RVK:
    XA 33000
    RVK:
    XA 10000
    Language: English
    Publisher: American Society of Hematology
    Publication Date: 2008
    detail.hit.zdb_id: 1468538-3
    detail.hit.zdb_id: 80069-7
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  • 10
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    Clinical Study of Autologous Cytokine-Induced Killer Cells for the Consolidation Treatment of Elderly Patients with Diffuse Large B-Cell Lymphoma
    American Society of Hematology ; 2014
    In:  Blood Vol. 124, No. 21 ( 2014-12-06), p. 4463-4463
    Details
    In: Blood, American Society of Hematology, Vol. 124, No. 21 ( 2014-12-06), p. 4463-4463
    Abstract: Cytokine-induced killer (CIK) cells are activated T cells with natural killer (NK) properties that can be expanded in vitro in presence of recombinant human interleukin-2 (rhIL-2) starting from peripheral blood mononuclear cells stimulated by interferon-γ and anti-CD3 antibody. They express CD3 and CD56 as well as the NKG2D antigen and show major histocompatibility complex (MHC)–unrestricted cytotoxicity toward neoplastic but not normal targets. CIK cells express several chemokine receptors, and in vivo models suggest that they can migrate to the site of tumors after intravenous administration, there carrying out their cytotoxic potential and helping to control tumor growth. CIK cells have shown cytotoxic activity in vitro and in vivo against hematopoietic neoplastic cells, including AML (acute myeloid leukemia), CML (chronic myelogenous leukemia), and CLL (chronic lymphocytic leukemia). Their cytotoxicity against patient with B-NHL (B-cell non-Hodgkin lymphoma) , however, has not been fully investigated. The elderly population is susceptible to haematological malignancies, and these elderly patients are intolerant to cytotoxic drugs. Therefore, the exploration of a safe and reliable strategy reduse dose of chemotherapy is critical in improving the prognosis of elderly patients with haematological malignancies. To evaluate the effectiveness and safety of autologous cytokine-induced killer (CIK) cells for consolidation treatmemt in elderly patients with diffuse large B-cell lymphoma. Peripheral blood mononuclear cells (PBMC) were isolated from 20 elderly patients with diffuse large B-cell lymphoma. PBMCs were augmented by priming with interferon gamma (IFN-γ) followed by IL-2 and monoclonal antibody (mAb) against CD3. Autologous CIK cells (range 5 × 10(9)-1 × 10(10)) were then infused back to individual patients. The regimen was repeated every 4 weeks. The host cellular immune function, tumour-related biological parameters, imaging characteristics, disease condition, quality of life and survival time were assessed. Fourteen patients received 6 cycles of transfusion and 6 received 4 cycles. After treatment of CIK cells plus IL-2, the general conditions of 20 patients were to different extent improved No adverse effects were observed. The percentages of CD3(+), CD3(+) CD8(+) and CD3(+) CD56(+) cells were significantly increased (p 〈 0.05), and the levels of serum β2 microglobulin and lactate dehydrogenase (LDH) were markedly decreased (p 〈 0.05) after autologous CIK cell transfusion. Cancer-related symptoms were profoundly alleviated, as demonstrated by the improved quality of life (p 〈 0.01)., Complete remission(CR) observed in 11 patients before the treatmemt of CIK was still CR; Partial remission(PR) in 9 patients ,After the treatmemt of CIK, the transformation of disease state from partial remission to complete remission was seen in 4 patients. At the end of follow-up, the mean survival time was 24 months. Transfusion with autologous CIK cells is safe and effective for treating haematological malignancies in elderly patients. Disclosures No relevant conflicts of interest to declare.
    Type of Medium: Online Resource
    ISSN: 0006-4971 , 1528-0020
    URL: Article
    DOI: 10.1182/blood.V124.21.4463.4463
    RVK:
    XA 33000
    RVK:
    XA 10000
    Language: English
    Publisher: American Society of Hematology
    Publication Date: 2014
    detail.hit.zdb_id: 1468538-3
    detail.hit.zdb_id: 80069-7
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