In:
Gynecologic and Obstetric Investigation, S. Karger AG, Vol. 84, No. 6 ( 2019), p. 575-582
Abstract:
〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 Endometriosis is a common disorder that affects 6–10% of reproductive age women. In a previous study, we demonstrated that a polymorphism in 〈 i 〉 let-7 〈 /i 〉 microRNA-binding site in the 3 & apos; untranslated region of the 〈 i 〉 KRAS 〈 /i 〉 gene was found in 31% of subjects with endometriosis resistant to medical therapy. This polymorphism was now tested in a large, case-control study. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 Peripheral blood or peritoneal biopsies from 2,077 European subjects with or without endometriosis and known infertility were tested for the presence of the variant allele using polymerase chain reaction. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 Histologically proven endometriosis was found in 1,140 subjects, while 937 subjects were disease free. Variant allele carrier rates in subjects with and without endometriosis were 15.7 and 15.1%, respectively. No association between the variant 〈 i 〉 KRAS 〈 /i 〉 allele and stage of the disease, age at surgery, body mass index, or type of infertility was identified. 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 A germ-line single-nucleotide polymorphism in the 〈 i 〉 let-7 〈 /i 〉 microRNA-binding site of the 〈 i 〉 KRAS 〈 /i 〉 gene was not associated with sporadic endometriosis in an infertile Caucasian population in this large case-control study. However, it remains possible that this gene variant may be a marker of treatment resistance. Further studies on the role of this polymorphism in endometriosis are needed.
Type of Medium:
Online Resource
ISSN:
0378-7346
,
1423-002X
Language:
English
Publisher:
S. Karger AG
Publication Date:
2019
detail.hit.zdb_id:
1482695-1
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