In:
American Journal of Clinical Pathology, Oxford University Press (OUP), Vol. 140, No. 4 ( 2013-10-01), p. 506-515
Abstract:
To examine whether the lipid parameters are predicting factors for human immunodeficiency virus (HIV)–associated lipodystrophy. Methods: Whole-body fat compositions of HIV-positive patients receiving stavudine-containing antiretroviral regimens (n = 79) were determined. Lipodystrophy was defined as a ratio of trunk fat mass/lower limb fat mass greater than 2.28. Blood samples were analyzed for total cholesterol (TC), triglycerides, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), small-dense LDL-C (sdLDL-C), apoAI, apoB, lipoprotein(a), and CD4 cell counts. Large-buoyant LDL-C (lbLDL-C) was calculated (LDL-C minus sdLDL-C). Results: Twenty-six patients were classified as having lipodystrophy. The mean values of triglycerides, HDL-C, sdLDL-C, apoB, TC/HDL-C, apolipoprotein (apo) B/apoAI, and sdLDL-C/lbLDL-C showed significant differences between patients with and without lipodystrophy (P & lt; .02). Using logistic regression analysis, sdLDL-C/lbLDL-C was identified as a significant predictor of lipodystrophy (P & lt; .001). At a ratio of 0.554, the odds ratio was 17.8 with a likelihood ratio of 5.5. Conclusions: The sdLDL-C/lbLDL-C ratio is an excellent marker for indicating lipodystrophy in HIV-infected patients.
Type of Medium:
Online Resource
ISSN:
1943-7722
,
0002-9173
DOI:
10.1309/AJCPE5I3KELTBXEJ
Language:
English
Publisher:
Oxford University Press (OUP)
Publication Date:
2013
detail.hit.zdb_id:
2039921-2
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