In:
Antimicrobial Agents and Chemotherapy, American Society for Microbiology, Vol. 52, No. 12 ( 2008-12), p. 4522-4525
Abstract:
We show that RsAFP2, a plant defensin that interacts with fungal glucosylceramides, is active against Candida albicans , inhibits to a lesser extent other Candida species, and is nontoxic to mammalian cells. Moreover, glucosylceramide levels in Candida species correlate with RsAFP2 sensitivity. We found RsAFP2 prophylactically effective against murine candidiasis.
Type of Medium:
Online Resource
ISSN:
0066-4804
,
1098-6596
DOI:
10.1128/AAC.00448-08
Language:
English
Publisher:
American Society for Microbiology
Publication Date:
2008
detail.hit.zdb_id:
1496156-8
SSG:
12
SSG:
15,3
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