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  • Comparative Studies. Non-European Languages/Literatures  (11)
  • 1
    Online Resource
    Online Resource
    The Chinese Western: Short Fiction from Today's China
    JSTOR ; 1989
    In:  World Literature Today Vol. 63, No. 2 ( 1989), p. 363-
    Details
    In: World Literature Today, JSTOR, Vol. 63, No. 2 ( 1989), p. 363-
    Type of Medium: Online Resource
    ISSN: 0196-3570
    URL: Article
    DOI: 10.2307/40145011
    RVK:
    EA 1000
    Language: English
    Publisher: JSTOR
    Publication Date: 1989
    detail.hit.zdb_id: 2067813-7
    detail.hit.zdb_id: 131663-1
    SSG: 7,12
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  • 2
    Online Resource
    Online Resource
    Noninvasive and cell-type specific neuromodulation by integrating ultrasound and genetics
    Acoustical Society of America (ASA) ; 2021
    In:  The Journal of the Acoustical Society of America Vol. 150, No. 4_Supplement ( 2021-10-01), p. A129-A129
    Details
    In: The Journal of the Acoustical Society of America, Acoustical Society of America (ASA), Vol. 150, No. 4_Supplement ( 2021-10-01), p. A129-A129
    Abstract: The investigation of brain functions and treatment of brain disorders requires modulation of selected neurons in a noninvasive manner in the deep brain. To achieve this goal, sonogenetics has been developed that involves the use of focused ultrasound (FUS) to selectively control a specific type of neurons that have been genetically modified to express ultrasound-sensitive ion channels. Existing sonogenetic techniques utilize ultrasound mechanical effect to activate mechanosensitive ion channels. Different from existing approaches, we aimed to develop sonothermogenetics for noninvasive, deep-penetrating, and cell-type-specific neuromodulation by combining a thermosensitive ion channel TRPV1 with FUS-induced brief, non-noxious thermal effect. FUS sonication at the mouse brain in vivo selectively activated neurons that were genetically modified to express TRPV1. Temporally precise activation of TRPV1-expressing neurons was achieved with its success rate linearly correlated with the peak average temperature within the FUS-targeted brain region as measured by in vivo magnetic resonance thermometry. FUS stimulation of TRPV1-expressing neurons of the Parkinsonian circuit at the striatum repeatedly evoked rotating locomotor behavior in freely moving mice. FUS sonication was confirmed to be safe based on inspection of neuronal integrity, inflammation, and apoptosis markers. In summary, our study demonstrated that sonothermogenetics is a noninvasive and cell-type-specific neuromodulation technique.
    Type of Medium: Online Resource
    ISSN: 0001-4966 , 1520-8524
    URL: Article
    DOI: 10.1121/10.0007863
    RVK:
    EQ 1000
    Language: English
    Publisher: Acoustical Society of America (ASA)
    Publication Date: 2021
    detail.hit.zdb_id: 1461063-2
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  • 3
    Online Resource
    Online Resource
    Intranasal administration of temozolomide combined with focused ultrasound to enhance the survival of mice with glioma (A Pilot Study)
    Acoustical Society of America (ASA) ; 2018
    In:  The Journal of the Acoustical Society of America Vol. 143, No. 3_Supplement ( 2018-03-01), p. 1732-1732
    Details
    In: The Journal of the Acoustical Society of America, Acoustical Society of America (ASA), Vol. 143, No. 3_Supplement ( 2018-03-01), p. 1732-1732
    Abstract: Intranasal route provides therapeutics direct access to the brain through the nose-to-brain pathway, bypassing the BBB and minimizing systemic exposure. However, nasal delivery is limited by its low delivery efficiency and non-localized delivery. Focused ultrasound-enhanced intranasal (FUSIN) delivery is a new technique for noninvasive and localized delivery of therapeutic agents to the brain. Previous studies have shown its feasibility in the delivery of dextrans and brain-derived neurotrophic factor to the brain. The goal of this study was to demonstrate the application of FUSIN for the delivery of temozolomide (TMZ), a first-line drug for treating glioma tumors, for the treatment of glioblastoma in an orthotopic mouse model. U87 glioblastoma cells were trancranially implanted to nude mice. The tumor mice were divided into four groups: (1) FUSIN + TMZ (n = 7); (2) IN TMZ (n = 6); (3) Oral TMZ (n = 6); and (4) IN vehicle (n = 6), and were treated once each week for 4 weeks. Mice were weighed once a week. A body weight loss reaching 20% was selected as the endpoint criteria for the study. Mice in FUSIN group showed statistically significant higher survival rate when compared with mice in all other groups. This pilot study suggested that FUSIN can potentially be an effective technique for the treatment of brain diseases.
    Type of Medium: Online Resource
    ISSN: 0001-4966 , 1520-8524
    URL: Article
    DOI: 10.1121/1.5035648
    RVK:
    EQ 1000
    Language: English
    Publisher: Acoustical Society of America (ASA)
    Publication Date: 2018
    detail.hit.zdb_id: 1461063-2
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  • 4
    Online Resource
    Online Resource
    Sonothermogenetics for noninvasive and cell-type specific deep brain neuromodulation
    Acoustical Society of America (ASA) ; 2021
    In:  The Journal of the Acoustical Society of America Vol. 149, No. 4_Supplement ( 2021-04-01), p. A119-A119
    Details
    In: The Journal of the Acoustical Society of America, Acoustical Society of America (ASA), Vol. 149, No. 4_Supplement ( 2021-04-01), p. A119-A119
    Abstract: This study aimed to develop sonothermogenetics for noninvasive, deep-penetrating, and cell-type-specific neuromodulation by combining a thermosensitive ion channel TRPV1 with focused ultrasound (FUS)-induced brief, non-noxious thermal effect. Sonothermogenetics is a noninvasive and cell-typespecific neuromodulation approach with the capability to target the deep brain.
    Type of Medium: Online Resource
    ISSN: 0001-4966 , 1520-8524
    URL: Article
    DOI: 10.1121/10.0004715
    RVK:
    EQ 1000
    Language: English
    Publisher: Acoustical Society of America (ASA)
    Publication Date: 2021
    detail.hit.zdb_id: 1461063-2
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  • 5
    Online Resource
    Online Resource
    Determination of the acoustic nonlinearity parameter in biological media using FAIS and ITD methods
    Acoustical Society of America (ASA) ; 1989
    In:  The Journal of the Acoustical Society of America Vol. 86, No. 1 ( 1989-07-01), p. 1-5
    Details
    In: The Journal of the Acoustical Society of America, Acoustical Society of America (ASA), Vol. 86, No. 1 ( 1989-07-01), p. 1-5
    Abstract: Two methods for determination of the acoustic nonlinearity parameter B/A in biological media are presented. One is the finite amplitude insert-substitution method (FAIS), considering the influence of both the sound attenuation of samples and the diffraction of the transducer on the experimental measurement. The other is the improved thermodynamic method (ITD), based on the measurement of phase shifts in the acoustic wave due to the change of ambient pressure. The nonlinearity parameter B/A has been measured for various biological solutions and soft tissues using these two methods. Some results of dependence of B/A values on the concentration and temperature are also presented here.
    Type of Medium: Online Resource
    ISSN: 0001-4966 , 1520-8524
    URL: Article
    DOI: 10.1121/1.398326
    RVK:
    EQ 1000
    Language: English
    Publisher: Acoustical Society of America (ASA)
    Publication Date: 1989
    detail.hit.zdb_id: 1461063-2
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  • 6
    Online Resource
    Online Resource
    Characterize brain tumor genetic signatures with focused ultrasound-enabled liquid biopsy
    Acoustical Society of America (ASA) ; 2020
    In:  The Journal of the Acoustical Society of America Vol. 148, No. 4_Supplement ( 2020-10-01), p. 2636-2636
    Details
    In: The Journal of the Acoustical Society of America, Acoustical Society of America (ASA), Vol. 148, No. 4_Supplement ( 2020-10-01), p. 2636-2636
    Abstract: Although blood-based liquid biopsy is a promising noninvasive diagnostic technique, the blood-brain barrier (BBB) hinders the efficient transport of brain tumor biomarkers into the bloodstream. In our previous studies, we demonstrated the feasibility for focused ultrasound-enabled liquid biopsy (FUS-LBx) to increase BBB permeability and enhance the transport of glioblastoma (GBM)-specific biomarkers into the bloodstream of mice using mRNA as a model biomarker. The objective of this study was to demonstrate the clinical translatability of FUS-LBx by evaluating the enhanced transport of the GBM-specific gene mutation, epidermal growth factor receptor variant III (EGFRvIII). Rats were randomly assigned to the treated (n = 10) or control groups (n = 6) 10 days after F98-EGFRvIII tumor cell implantation. MRI scans guided the combined FUS and microbubble sonication to the tumor center and verified successful BBB disruption. Blood was collected after FUS sonication or sham treatment. Droplet digital polymerase chain reaction was used to analyze the EGFRvIII complementary DNA. Rat brains were collected for histological analysis of potential FUS-induced tissue damage. MRI scans confirmed successful FUS-induced BBB opening. The EGFRvIII mutation that was undetectable by conventional LBx (no FUS), was detected by FUS-LBx. Histological analysis showed no significant tissue damage caused by FUS. This study demonstrated that FUS-LBx has the clinical translational potential for the noninvasive characterization of the GBM genetic profiles.
    Type of Medium: Online Resource
    ISSN: 0001-4966 , 1520-8524
    URL: Article
    DOI: 10.1121/1.5147328
    RVK:
    EQ 1000
    Language: English
    Publisher: Acoustical Society of America (ASA)
    Publication Date: 2020
    detail.hit.zdb_id: 1461063-2
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  • 7
    Online Resource
    Online Resource
    Recent progress in coastal acoustic tomography
    Acoustical Society of America (ASA) ; 2016
    In:  Journal of the Acoustical Society of America Vol. 140, No. 4_Supplement ( 2016-10-01), p. 3135-3136
    Details
    In: Journal of the Acoustical Society of America, Acoustical Society of America (ASA), Vol. 140, No. 4_Supplement ( 2016-10-01), p. 3135-3136
    Abstract: Coastal acoustic tomography (CAT) which was proposed by Hiroshima University in 1990s as a shallow-sea application of ocean acoustic tomography (OAT) is developed as a mirror-type CAT (MCAT) for measuring deep strait throughflows in Indonesian archipelago seas in real time. MCAT system is composed of a land station (M0) connected to a 100 m submarine cable edged by a 5 kHz subsurface transceiver and triangular-arrayed bottom-moored stations (M1, M2, and M3). Reciprocal data are first obtained among three station pairs (M1M2, M2M3, and M3M1). Data received at M1 from M2 and M3 are transferred to the land station (M0) by the first mirror reflection, resulting in travel time summations (t21 + t10, t31 + t10) (t21: travel time from M2 to M1). Data obtained at the offshore stations M2 and M3 are transferred to the nearshore station M1 by the first mirror reflection, resulting in travel time summations (t12 + t21, t13 + t31, t23 + t31, and t32 + t21). All the first mirror data at M1 are also transferred to M0 by the second mirror reflection, adding a travel time by t10 for the above four travel time summations. Finally, travel time differences are calculated for M0M1, M1M2, M2M3, and M3M1 by subtracting the summation data at M0. They are converted to path-average currents along the four transmission lines, succeeding in strait throughflow estimate. The mirror reflection function of MCAT can develop in an underwater transfer system of sound from moving sources by adding a hydrophone.
    Type of Medium: Online Resource
    ISSN: 0001-4966 , 1520-8524
    URL: Article
    DOI: 10.1121/1.4969824
    RVK:
    EQ 1000
    Language: English
    Publisher: Acoustical Society of America (ASA)
    Publication Date: 2016
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  • 8
    Online Resource
    Online Resource
    Focused ultrasound-mediated microbubble destruction for glioblastoma treatment
    Acoustical Society of America (ASA) ; 2019
    In:  The Journal of the Acoustical Society of America Vol. 145, No. 3_Supplement ( 2019-03-01), p. 1862-1862
    Details
    In: The Journal of the Acoustical Society of America, Acoustical Society of America (ASA), Vol. 145, No. 3_Supplement ( 2019-03-01), p. 1862-1862
    Abstract: Glioblastoma is the most common primary brain tumor with a poor prognosis despite advances in various treatment modalities, such as radiation therapy (RT). This study compared the tumor growth inhibition effects of focused ultrasound-targeted microbubble destruction (UTMD) therapy with the RT using an orthotopic mouse glioma model. Mice were implanted with GL261 glioblastoma cells and divided into three groups: control group (no treatment); RT group (2 Gy/day, 5 days/week, 3 consecutive weeks); and UTMD group (FUS sonication in the presence of systemically injected microbubbles at the peak negative pressure of 1.5 MPa, frequency of 1.44 MHz, and 2 treatments/week for 3 consecutive weeks). Contrast-enhanced magnetic resonance imaging (MRI) was performed once every four days for measuring the tumor volume. Both UTMD and RT caused significant growth inhibition compared to the control group; however, there was no significant difference between the UTMD and RT groups. Terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) staining showed that the number of apoptotic tumor cells in both RT and UTMD groups were significantly higher than the control group without the difference between these two groups. This study suggests that UTMD suppressed glioblastoma tumor growth and this effect was comparable with that achieved by RT.
    Type of Medium: Online Resource
    ISSN: 0001-4966 , 1520-8524
    URL: Article
    DOI: 10.1121/1.5101727
    RVK:
    EQ 1000
    Language: English
    Publisher: Acoustical Society of America (ASA)
    Publication Date: 2019
    detail.hit.zdb_id: 1461063-2
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  • 9
    Online Resource
    Online Resource
    FUS-LBx: Focused ultrasound-enabled brain tumor liquid biopsy for noninvasive brain cancer diagnosis
    Acoustical Society of America (ASA) ; 2019
    In:  The Journal of the Acoustical Society of America Vol. 146, No. 4_Supplement ( 2019-10-01), p. 2990-2990
    Details
    In: The Journal of the Acoustical Society of America, Acoustical Society of America (ASA), Vol. 146, No. 4_Supplement ( 2019-10-01), p. 2990-2990
    Abstract: Focused ultrasound (FUS) in combination with microbubbles has been studied extensively as a blood-brain barrier (BBB) disruption tool for the delivery of drugs in the blood circulation to the brain parenchyma. Recently, we introduced the hypothesis that FUS-mediated BBB disruption could be viewed as a tool for enhancing “two-way trafficking” between brain and blood. While circulating molecules can be allowed to enter the brain using FUS-mediated BBB disruption, brain tumor biomarkers can also be released into the blood circulation for liquid biopsies. Based on this hypothesis, we proposed to develop FUS-enabled brain tumor liquid biopsy technique (FUS-LBx), which uses FUS in combination with microbubbles to enhance the release of biomarkers from brain tumors into the blood circulation for liquid biopsies. We performed a proof-of-concept study and demonstrated the feasibility of FUS-LBx for the local release of mRNA from glioblastoma tumors in mice into the bloodstream for liquid biopsies. We also optimize the FUS-LBx technique by investigating the effects of FUS acoustic pressure on the tumor biomarker release level and potentially associated hemorrhage burden. We found that FUS-LBx technique can be optimized to be a safe and effective image-guided biomarker release technique. We developed an MR-compatible FUS system for FUS-LBx application in a porcine model and demonstrated the feasibility and safety of FUS-LBx in the large animal model. In summary, FUS-LBx is a promising tool for brain tumor diagnosis.
    Type of Medium: Online Resource
    ISSN: 0001-4966 , 1520-8524
    URL: Article
    DOI: 10.1121/1.5137350
    RVK:
    EQ 1000
    Language: English
    Publisher: Acoustical Society of America (ASA)
    Publication Date: 2019
    detail.hit.zdb_id: 1461063-2
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  • 10
    Online Resource
    Online Resource
    Sound spectra of ancient Chinese bells in the Shanghai Museum
    Acoustical Society of America (ASA) ; 1989
    In:  The Journal of the Acoustical Society of America Vol. 85, No. S1 ( 1989-05-01), p. S33-S33
    Details
    In: The Journal of the Acoustical Society of America, Acoustical Society of America (ASA), Vol. 85, No. S1 ( 1989-05-01), p. S33-S33
    Abstract: Sound spectra were obtained from ten bells from the 5th–12th centuries BC by striking them at the appropriate sui and gu locations. Although considerably different in size, shape, and ornamentation, all the bells had oval cross sections and thus exhibited two-tone behavior [T. D. Rossing et al., J. Acoust. Soc. Am. 83, 369 (1988)]. Frequency ratios of the two fundamental (2,0) modes range from 1.11–1.31 (181–473 ¢). In most spectra, it is possible to identify two partials most likely associated with two (3,0) modes that have frequencies 2.32–3.29 times the lowest (2,0) mode. The spectra of these bells are compared to those of other Chinese bells, including those of the renowned Zenghou Yi.
    Type of Medium: Online Resource
    ISSN: 0001-4966 , 1520-8524
    URL: Article
    DOI: 10.1121/1.2026917
    RVK:
    EQ 1000
    Language: English
    Publisher: Acoustical Society of America (ASA)
    Publication Date: 1989
    detail.hit.zdb_id: 1461063-2
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