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  • Comparative Studies. Non-European Languages/Literatures  (14)
  • 1
    Online Resource
    Online Resource
    Comparison of pathway in high-intensity focused ultrasound lesion production
    Acoustical Society of America (ASA) ; 2007
    In:  The Journal of the Acoustical Society of America Vol. 122, No. 5_Supplement ( 2007-11-01), p. 3007-3008
    Details
    In: The Journal of the Acoustical Society of America, Acoustical Society of America (ASA), Vol. 122, No. 5_Supplement ( 2007-11-01), p. 3007-3008
    Abstract: High intensity focused ultrasound (HIFU) is being evaluated for noninvasive treatment of solid tumors. The temperature at the HIFU focus can reach over 65 & lt;th & gt;°C, denaturing cellular proteins and resulting in coagulative necrosis and lesion formation. One common method for delivering HIFU therapy clinically is using the spot accumulation method that delivers sequential individual treatment spots. Because of thermal diffusion from nearby treatment spots, the size of subsequent lesions will gradually become larger as the HIFU therapy progresses, which may cause insufficient treatment of the initial spots, and over-treatment of later spots unless parameters are changed during treatment. A new pathway for HIFU treatment is proposed and compared with the conventional sequential path. Modeling, in vitro phantom and ex vivo bovine liver experiments demonstrate that the new treatment path produces more uniform lesions than the conventional treatment path (p & lt;0.05). The relationship between lesion area/volume and delivered ultrasound energy and the dose-dependent discrepancies between scanning paths were also studied. In addition, the temperature changes in the ex vivo system were measured using a thermocouple array. Altogether, the new treatment path appears to be advantageous for producing more uniform lesions without modifying HIFU parameters during treatment or significantly increasing the scanning time.
    Type of Medium: Online Resource
    ISSN: 0001-4966 , 1520-8524
    URL: Article
    DOI: 10.1121/1.2942742
    RVK:
    EQ 1000
    Language: English
    Publisher: Acoustical Society of America (ASA)
    Publication Date: 2007
    detail.hit.zdb_id: 1461063-2
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  • 2
    Online Resource
    Online Resource
    High intensity focused ultrasound-induced bubbles stimulate the release of nucleic acid cancer biomarkers
    Acoustical Society of America (ASA) ; 2014
    In:  The Journal of the Acoustical Society of America Vol. 136, No. 4_Supplement ( 2014-10-01), p. 2278-2278
    Details
    In: The Journal of the Acoustical Society of America, Acoustical Society of America (ASA), Vol. 136, No. 4_Supplement ( 2014-10-01), p. 2278-2278
    Abstract: Recently, several nucleic acid cancer biomarkers, e.g., microRNA and mutant DNA, have been identified and shown promise for improving cancer diagnostics. However, the abundance of these biomarker classes in the circulation is low, impeding reliable detection and adoption into clinical practice. Here, the ability of HIFU-induced bubbles to stimulate release of cancer-associated microRNAs by tissue fractionation or permeabilization was investigated in a heterotopic syngeneic rat prostate cancer model. A 1.5 MHz HIFU transducer was used to either mechanically fractionate subcutaneous tumor with boiling histotripsy (BH) (~20 kW/cm2, 10 ms pulses, and duty factor 0.01) or to permeabilize tumor tissue with inertial cavitation activity (p- = 16 MPa, 1 ms pulses, duty factor 0.001). Blood was collected immediately prior to and serially up to 24-hours after treatments. Plasma concentrations of microRNAs were measured by quantitative RT-PCR. Both exposures resulted in a rapid (within 15 min), short (≤3 h) and dramatic (over ten-fold) increase in relative plasma concentrations of tumor-associated microRNAs, Histologic examination of excised tumor confirmed complete fractionation of targeted tumor by BH and localized areas of intraparenchymal hemorrhage and tissue disruption by cavitation-based treatment. These data suggest a clinically useful application of HIFU-induced bubbles for non-invasive molecular biopsy. [Grant support: NIH 1K01EB015745, R01CA154451, R01DK085714.]
    Type of Medium: Online Resource
    ISSN: 0001-4966 , 1520-8524
    URL: Article
    DOI: 10.1121/1.4900232
    RVK:
    EQ 1000
    Language: English
    Publisher: Acoustical Society of America (ASA)
    Publication Date: 2014
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  • 3
    Online Resource
    Online Resource
    The use of twinkling artifact of Doppler imaging to monitor cavitation in tissue during high intensity focused ultrasound therapy
    Acoustical Society of America (ASA) ; 2013
    In:  The Journal of the Acoustical Society of America Vol. 133, No. 5_Supplement ( 2013-05-01), p. 3315-3315
    Details
    In: The Journal of the Acoustical Society of America, Acoustical Society of America (ASA), Vol. 133, No. 5_Supplement ( 2013-05-01), p. 3315-3315
    Abstract: In high intensity focused ultrasound (HIFU) therapy, it is important to monitor the presence and activity of microbubbles in tissue during treatment. The current methods—passive cavitation detection (PCD) and B-mode imaging—have limited sensitivity, especially to small-size, non-violently collapsing microbubbles. Here, a new method for microbubble detection is proposed, based on “twinkling” artifact (TA) of Doppler imaging. TA occurs when color Doppler ultrasound is used to image hard objects in tissue (e.g., kidney stones) and is displayed as brightly colored spots. As demonstrated recently, TA can be explained by irregular scattering of the Doppler ensemble pulses from the fluctuating microbubbles trapped in crevices of the kidney stone. In this work, TA was used to detect cavitation in tissue and in polyacrylamide gel phantoms during pulsed 1 MHz HIFU exposures with different peak negative pressures (1.5–11 MPa). At each pressure level, the probability of cavitation occurrence was characterized using TA and the broadband signals recorded by PCD, aligned confocally with the HIFU transducer. The results indicate that TA is more sensitive to the onset of cavitation than conventional PCD detection, and allows for accurate spatial localization of the bubbles. [Work supported by RFBR and NIH (EB007643, 1K01EB015745, and R01CA154451).]
    Type of Medium: Online Resource
    ISSN: 0001-4966 , 1520-8524
    URL: Article
    DOI: 10.1121/1.4805522
    RVK:
    EQ 1000
    Language: English
    Publisher: Acoustical Society of America (ASA)
    Publication Date: 2013
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  • 4
    Online Resource
    Online Resource
    A method of mechanical emulsification in a bulk tissue using shock wave heating and millisecond boiling.
    Acoustical Society of America (ASA) ; 2011
    In:  The Journal of the Acoustical Society of America Vol. 129, No. 4_Supplement ( 2011-04-01), p. 2476-2476
    Details
    In: The Journal of the Acoustical Society of America, Acoustical Society of America (ASA), Vol. 129, No. 4_Supplement ( 2011-04-01), p. 2476-2476
    Abstract: Recent studies in high intensity focused ultrasound (HIFU) have shown significant interest in generating purely mechanical damage of tissue without thermal coagulation. Here, an approach using millisecond bursts of ultrasound shock waves and repeated localized boiling is presented. In HIFU fields, nonlinear propagation effects lead to formation of shocks only in a small focal region. Significant enhancement of heating due to absorption at the shocks leads to boiling temperatures in tissue in milliseconds as calculated based on weak shock theory. The heated and potentially necrotized region of tissue is small compared to the volume occupied by the mm-sized boiling bubble it creates. If the HIFU pulse is only slightly longer than the time-to-boil, thermal injury is negligible compared to the mechanical injury caused by the exploding boiling bubble and its further interaction with shocks. Experiments performed in transparent gels and various ex vivo and in vivo tissues have confirmed the effectiveness of this emulsification method. In addition, since mm-sized boiling bubbles are highly echogenic, tissue emulsification can be easily monitored in real-time using B-mode ultrasound imaging. [Work supported by NIH EB007643, RFBR 09-02-01530, and NSBRI through NASA NCC 9-58] .
    Type of Medium: Online Resource
    ISSN: 0001-4966 , 1520-8524
    URL: Article
    DOI: 10.1121/1.3588143
    RVK:
    EQ 1000
    Language: English
    Publisher: Acoustical Society of America (ASA)
    Publication Date: 2011
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  • 5
    Online Resource
    Online Resource
    Challenges of clinical high intensity focused ultrasound: The need for metrology.
    Acoustical Society of America (ASA) ; 2011
    In:  The Journal of the Acoustical Society of America Vol. 129, No. 4_Supplement ( 2011-04-01), p. 2403-2403
    Details
    In: The Journal of the Acoustical Society of America, Acoustical Society of America (ASA), Vol. 129, No. 4_Supplement ( 2011-04-01), p. 2403-2403
    Abstract: Metrology of high intensity focused ultrasound (HIFU) is critical to the advancement of clinical application of HIFU for safe and effective treatments in patients. Several methods for performing metrology of HIFU systems are available in the research laboratory setting; however, translation of these methods to the clinical setting remains in evolution. From our initial experience with clinical HIFU systems we have realized the importance of accurate acoustic characterization of HIFU systems in order to determine the parameters of the treatment protocol to result in safe and effective treatments. The acoustic parameters of the system, particularly at very high intensities, are very important to understand prior to delivering HIFU therapy to patients. Improved methods of HIFU metrology, especially to determine in situ exposure and dose, will result in a more rational approach to clinical HIFU therapy. Further advances in clinical HIFU therapy will require close cooperation between clinicians and scientists in order to make HIFU therapy safe and effective. Educating clinicians on the importance of metrology will also be important. [Work supported by NIH Grant No. EB007643.]
    Type of Medium: Online Resource
    ISSN: 0001-4966 , 1520-8524
    URL: Article
    DOI: 10.1121/1.3587823
    RVK:
    EQ 1000
    Language: English
    Publisher: Acoustical Society of America (ASA)
    Publication Date: 2011
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  • 6
    Online Resource
    Online Resource
    In vivo tissue emulsification using millisecond boiling induced by high intensity focused ultrasound.
    Acoustical Society of America (ASA) ; 2011
    In:  The Journal of the Acoustical Society of America Vol. 129, No. 4_Supplement ( 2011-04-01), p. 2477-2477
    Details
    In: The Journal of the Acoustical Society of America, Acoustical Society of America (ASA), Vol. 129, No. 4_Supplement ( 2011-04-01), p. 2477-2477
    Abstract: Shock-wave heating and millisecond boiling in high intensity focused ultrasound fields have been shown to result in mechanical emulsification of ex-vivo tissue. In this work, the same in situ exposures were applied in vivo in pig liver and in mice bearing 5–7 mm subcutaneous tumors (B16 melanoma) on the hind limb. Lesions were produced using a 2-MHz annular array in the case of pig liver (shock amplitudes up to 98 MPa) and a 3.4-MHz single-element transducer in the case of mouse tumors (shock amplitude of 67 MPa). The parameters of the pulsing protocol (1–500 ms pulse durations and 0.01–0.1 duty factor) were varied depending on the extent of desired thermal effect. All exposures were monitored using B-mode ultrasound. Mechanical and thermal tissue damage in the lesions was evaluated histologically using H & E and NADH-diphorase staining. The size and shape of emulsified lesions obtained in-vivo agreed well with those obtained in ex-vivo tissue samples using the same exposure parameters. The lesions were successfully produced both in bulk liver tissue at depths of 1–2 cm and in superficial tumors at depths less than 1 mm without damaging the skin. [Work supported by NIH (DK070618, EB007643, and DK007742) and NSBRI through NASA NCC 9-58.]
    Type of Medium: Online Resource
    ISSN: 0001-4966 , 1520-8524
    URL: Article
    DOI: 10.1121/1.3588149
    RVK:
    EQ 1000
    Language: English
    Publisher: Acoustical Society of America (ASA)
    Publication Date: 2011
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  • 7
    Online Resource
    Online Resource
    Occlusive thrombosis in the rabbit auricular vein in vivo targeted by induction of intralumenal cavitation using HIFU and ultrasound contrast agent
    Acoustical Society of America (ASA) ; 2005
    In:  The Journal of the Acoustical Society of America Vol. 117, No. 4_Supplement ( 2005-04-01), p. 2558-2558
    Details
    In: The Journal of the Acoustical Society of America, Acoustical Society of America (ASA), Vol. 117, No. 4_Supplement ( 2005-04-01), p. 2558-2558
    Abstract: Hypotheses tested: (1) inertial cavitation [IC] could be induced in the venous lumen in vivo by combined use of intravascular microbubble contrast agent and transcutaneous application of 1-MHz high intensity focused ultrasound [HIFU] of very low duty factor, and that IC activity could be detected and quantified in vivo as in earlier in vitro studies via passive cavitation detection methods; (2) robust IC activity would damage the venous endothelium in treated regions; (3) endothelial damage would be proportional to the IC dose developed in the region; (4) severe local endothelial damage alone may be sufficient to induce occlusive thrombosis, or may sensitize the region to low systemic doses of prothrombotic agents, and (5) biologically significant temperature rises and attendant thermal bioeffects in the vessel and perivascular tissues would not occur, even under the highest amplitude acoustic conditions applied. Each hypothesis was supported by the data. The principal result was that under treatment conditions involving very high peak negative acoustic pressures and contrast agent, treated areas thrombosed acutely but non-occlusively. When fibrinogen was administered locally after such treatment, occlusive thrombi formed acutely and only in the treated region, a response observed with none of the other treatments.
    Type of Medium: Online Resource
    ISSN: 0001-4966 , 1520-8524
    URL: Article
    DOI: 10.1121/1.4788511
    RVK:
    EQ 1000
    Language: English
    Publisher: Acoustical Society of America (ASA)
    Publication Date: 2005
    detail.hit.zdb_id: 1461063-2
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  • 8
    Online Resource
    Online Resource
    Twinkling artifact of Doppler imaging for cavitation detection during high-intensity focused ultrasound therapy: Sensitivity and resolution
    Acoustical Society of America (ASA) ; 2013
    In:  The Journal of the Acoustical Society of America Vol. 134, No. 5_Supplement ( 2013-11-01), p. 3976-3976
    Details
    In: The Journal of the Acoustical Society of America, Acoustical Society of America (ASA), Vol. 134, No. 5_Supplement ( 2013-11-01), p. 3976-3976
    Abstract: The mechanism of the twinkling artifact (TA) during Doppler imaging of kidney stones is well-known and is hypothesized to stem from the irregular scattering of Doppler ensemble pulses from fluctuating microbubbles trapped in crevices of the kidney stone. We have previously demonstrated that the TA can be used to detect and image microbubbles in soft tissue during pulsed HIFU treatment. In this work, the characteristics of the method—the sensitivity to small bubbles and the spatial resolution—were investigated experimentally and compared to other passive and active cavitation imaging methods such as pulse inversion. An approach was proposed for quantification of the cavitation images provided by the method, and the resulting metric was compared to the inertial cavitation dose. The experiments were performed using pulsed 1-MHz HIFU exposures of transparent gel phantoms, ex vivo tissue and in vivo mouse model of pancreatic cancer. [Work supported by RFBR and NIH (EB007643, 1K01EB015745, and R01CA154451).]
    Type of Medium: Online Resource
    ISSN: 0001-4966 , 1520-8524
    URL: Article
    DOI: 10.1121/1.4830486
    RVK:
    EQ 1000
    Language: English
    Publisher: Acoustical Society of America (ASA)
    Publication Date: 2013
    detail.hit.zdb_id: 1461063-2
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  • 9
    Online Resource
    Online Resource
    Passive and active Doppler methods and metrics to quantify inertial cavitation induced by pulsed focused ultrasound
    Acoustical Society of America (ASA) ; 2022
    In:  The Journal of the Acoustical Society of America Vol. 152, No. 4_Supplement ( 2022-10-01), p. A215-A215
    Details
    In: The Journal of the Acoustical Society of America, Acoustical Society of America (ASA), Vol. 152, No. 4_Supplement ( 2022-10-01), p. A215-A215
    Abstract: Inertial cavitation induced by pulses of nonlinearly distorted focused ultrasound (FUS) at moderate intensity can result in mild mechanical disruption of tissue, short of its complete mechanical disintegration—histotripsy. This effect can be used to enhance diffusion of subsequently systemically administered drugs or biologics. Previously, single-element passive cavitation detection (PCD) of broadband noise emissions was successfully used to quantify tissue disruption and enhancement in drug concentration. This metric, however, has limitations: minimal spatial resolution and challenges with calibration when used at large depths in acoustically variable tissue. To address this, we developed a combination of passive and active Doppler-based methods that relied on relative, rather than absolute signal metrics. Specifically, destructive cavitation behaviors were previously linked to substantial motion of the bubbles during the FUS pulse due to acoustic radiation force and shock scattering. This was reflected in the backscattered FUS harmonics as Doppler shift and measurable from PCD. The bubbles were observed to dissolve within milliseconds following each FUS pulse, thus their distribution could be visualized as an area of rapid change via fast plane wave Doppler ensemble following the FUS pulse. The Doppler power distribution was spatially correlated with the area of tissue disruption in the in vivo experiments. [Work supported by NIH R01CA154451, R01EB025187, and R01EB23910.]
    Type of Medium: Online Resource
    ISSN: 0001-4966 , 1520-8524
    URL: Article
    DOI: 10.1121/10.0016055
    RVK:
    EQ 1000
    Language: English
    Publisher: Acoustical Society of America (ASA)
    Publication Date: 2022
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  • 10
    Online Resource
    Online Resource
    Passive and Doppler-based assessment of cavitation activity induced by pulsed focused ultrasound
    Acoustical Society of America (ASA) ; 2022
    In:  The Journal of the Acoustical Society of America Vol. 152, No. 4_Supplement ( 2022-10-01), p. A249-A250
    Details
    In: The Journal of the Acoustical Society of America, Acoustical Society of America (ASA), Vol. 152, No. 4_Supplement ( 2022-10-01), p. A249-A250
    Abstract: Pulsed focused ultrasound (pFUS) exposures utilizing short, nonlinearly distorted pulses at low duty cycle have been shown to enhance drug and gene delivery to targeted tissue through inertial cavitation activity. Passive cavitation detection (PCD) and mapping of broadband emissions are current conventional methods to monitor and quantify cavitation but provide limited spatial resolution. Here, plane-wave Doppler imaging was used with PCD to quantify pFUS-induced cavitation in ex vivo bovine tissues and in vivo surgically exposed porcine liver, kidney, and pancreas. A 1.5 MHz FUS transducer (aperture 75 mm, F-number 0.75) was used to deliver 60 pulses (duration 1 ms, 0.1% duty cycle, focal pressure p+ = 70i–110 MPa, p− = 13–20 MPa). A coaxially mounted ATL P7-4 ultrasound imaging probe was used for PCD during the FUS pulse, and Doppler and B-mode sequences. Disrupted tissue areas were collected for histology and compared to Doppler power images. Maximum Doppler power was found to correlate to broadband noise level for each FUS pulse. The Doppler power map integrated over the exposure was observed to correlate spatially with tissue disruption area from histology, which thus represents a promising real-time metric for quantifying cavitation activity induced by pFUS exposures. [Work supported by NIH R01CA154451, R01EB025187, and R01EB23910.]
    Type of Medium: Online Resource
    ISSN: 0001-4966 , 1520-8524
    URL: Article
    DOI: 10.1121/10.0016171
    RVK:
    EQ 1000
    Language: English
    Publisher: Acoustical Society of America (ASA)
    Publication Date: 2022
    detail.hit.zdb_id: 1461063-2
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