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  • Comparative Studies. Non-European Languages/Literatures  (6)
  • 1
    Online Resource
    Online Resource
    Correlation of vasoconstriction and kidney protection during shock wave lithotripsy
    Acoustical Society of America (ASA) ; 2008
    In:  The Journal of the Acoustical Society of America Vol. 123, No. 5_Supplement ( 2008-05-01), p. 3367-3367
    Details
    In: The Journal of the Acoustical Society of America, Acoustical Society of America (ASA), Vol. 123, No. 5_Supplement ( 2008-05-01), p. 3367-3367
    Abstract: Kidney injury in lithotripsy can lead to long-term adverse effects, so minimizing injury is beneficial. We have found that injury is significantly reduced when shock wave (SW) administration is halted briefly- 3-minutes-early in treatment. Previous studies have shown that SWs stimulate renal blood vessels to constrict. Therefore, we tested the idea that vasoconstriction mediates SW-induced protection of the kidney. Doppler ultrasound was used to measure resistive index (RI), a ratio of systolic and diastolic velocities, indicating vasoconstriction. RI was determined for single intralobar arteries in targeted porcine kidneys treated by standard versus protection protocols (2,000SW, uninterrupted vs 500SW-3-min pause-2,000SW) using a Dornier-HM3 lithotripter (2Hz, 24kV). Significant differences in RI from baseline within a group and between groups at various time points were determined using mixed-effect models for repeated measures with Holm's step-down method for multiple comparison adjustment. All animals had similar baselines. Sham pigs (no-SWs) showed no significant change in RI. The protection protocol produced a significant rise (p & lt;0.05, n=8) in RI 15 minutes into treatment, while the standard protocol did not yield a significant rise (p & lt;0.05, n=7) until 45 minutes after treatment. Thus, the treatment protocol shown to protect against injury, induces early vasoconstriction. [NIH-DK43881, NSBRI-SMS00402]
    Type of Medium: Online Resource
    ISSN: 0001-4966 , 1520-8524
    URL: Article
    DOI: 10.1121/1.2933974
    RVK:
    EQ 1000
    Language: English
    Publisher: Acoustical Society of America (ASA)
    Publication Date: 2008
    detail.hit.zdb_id: 1461063-2
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  • 2
    Online Resource
    Online Resource
    Renal heme oxygenase-1 upregulation after shock wave lithotripsy.
    Acoustical Society of America (ASA) ; 2009
    In:  The Journal of the Acoustical Society of America Vol. 125, No. 4_Supplement ( 2009-04-01), p. 2620-2620
    Details
    In: The Journal of the Acoustical Society of America, Acoustical Society of America (ASA), Vol. 125, No. 4_Supplement ( 2009-04-01), p. 2620-2620
    Abstract: Shock wave lithotripsy (SWL) is known to induce oxidative stress and a rapid inflammatory response in renal tissue. The purpose of this study was to determine the location and quantify markers for oxidative stress and inflammation in a porcine model of acute SWL-induced renal injury. The lower pole calyx of left kidneys of female pigs received 2000 shock waves at 24 kV/2 Hz from a Dornier HM3 lithotripter and subsequently monitored for 4 h. Heme oxygenase-1 protein (HO-1) was measured in renal microsomes by Western blot. Renal medulla HO-1/β-actin ratios were 1.186 ± 0.48 for treated pole (F2), 0.293 ± 0.23 for treated kidney upper pole, and 0.122 ± 0.075 for contralateral kidney (n=6). Thus, we observed an eightfold induction of HO-1 in renal medulla at F2 compared to the upper pole medulla of the treated kidney and the contralateral kidney medulla. In contrast, renal cortex at F2 did not show a similar HO-1 induction. The highly localized HO-1 induction in SWL-treated renal medulla parallels our previously reported finding of interleukin-6. These data together suggest that an early inflammatory response and oxidative stress appear primarily in the treated renal medulla within 4 h after SWL. [Work supported by NIH].
    Type of Medium: Online Resource
    ISSN: 0001-4966 , 1520-8524
    URL: Article
    DOI: 10.1121/1.4783983
    RVK:
    EQ 1000
    Language: English
    Publisher: Acoustical Society of America (ASA)
    Publication Date: 2009
    detail.hit.zdb_id: 1461063-2
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  • 3
    Online Resource
    Online Resource
    Exploring the limits of treatment used to invoke protection from extracorporeal shock wave lithotripsy induced injury
    Acoustical Society of America (ASA) ; 2014
    In:  The Journal of the Acoustical Society of America Vol. 136, No. 4_Supplement ( 2014-10-01), p. 2191-2192
    Details
    In: The Journal of the Acoustical Society of America, Acoustical Society of America (ASA), Vol. 136, No. 4_Supplement ( 2014-10-01), p. 2191-2192
    Abstract: Previous studies with our juvenile pig model have shown that a clinical dose of 2000 shock waves (SWs) (Dornier HM-3, 24 kV, 120 SWs/min) produces a lesion ~3–5% of the functional renal volume (FRV) of the SW-treated kidney. This injury was significantly reduced (to ~0.4% FRV) when a priming dose of 500 low-energy SWs immediately preceded this clinical dose, but not when using a priming dose of 100 SWs [BJU Int. 110, E1041 (2012)]. The present study examined whether using only 300 priming dose SWs would initiate protection against injury. METHODS: Juvenile pigs were treated with 300 SW’s (12 kV) delivered to a lower pole calyx using a HM-3 lithotripter. After a pause of 10 s, 2000 SWs (24 kV) were delivered to that same kidney. The kidneys were then perfusion-fixed and processed to quantitate the size of the parenchymal lesion. RESULTS: Pigs (n = 9) treated using a protocol with 300 low-energy priming dose SWs had a lesion measuring 0.84±0.43% FRV (mean ± SE). This lesion was smaller than that seen with a clinical dose of 2000 SWs at 24 kV. CONCLUSIONS: A treatment protocol including 300 low-energy priming dose SWs can provide protection from injury during shock wave lithotripsy. [Research supported by NIH grant P01 DK43881.]
    Type of Medium: Online Resource
    ISSN: 0001-4966 , 1520-8524
    URL: Article
    DOI: 10.1121/1.4899943
    RVK:
    EQ 1000
    Language: English
    Publisher: Acoustical Society of America (ASA)
    Publication Date: 2014
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  • 4
    Online Resource
    Online Resource
    Acoustic characterization and assessment of renal injury with a broad focal width electrohydraulic lithotripter
    Acoustical Society of America (ASA) ; 2013
    In:  The Journal of the Acoustical Society of America Vol. 134, No. 5_Supplement ( 2013-11-01), p. 4213-4213
    Details
    In: The Journal of the Acoustical Society of America, Acoustical Society of America (ASA), Vol. 134, No. 5_Supplement ( 2013-11-01), p. 4213-4213
    Abstract: This study provides an independent assessment of a novel lithotripter (LG-380, Tissue Regeneration Technologies), marketed as having a long-life self-adjusting spark gap electrode and producing a low-pressure, broad-focal-zone acoustic field. For acoustic characterization we coupled the therapy head of the lithotripter to a water tank and mapped the field using a fiber-optic hydrophone (FOPH-500, RP Acoustics). At the target point of the lithotripter, the peak positive pressure (P +) remained relatively stable (~19±5 MPa at power level 9) during the 6000 shock waves (SWs) lifetime of the electrode. The position of maximum P + (~35 MPa at PL9) was 35mm distal to target point and shifted progressively toward the therapy head as the electrode aged, reaching the target point (while reducing to P + ~20 MPa) after ~5000 SWs. This was likely due to a slight movement in position of the self-adjusting spark gap—changing the focus of the shock wave and the dimensions of the focal volume of the lithotripter. Kidney injury was assessed using an established pig model by routine measures of renal function and quantitation of lesion size. Simulated clinical treatments (3000 SWs dose) damaged & lt;0.1% functional renal volume, suggesting minimal potential for adverse effects with low-pressure broad-focal-zone lithotripters. [NIH DK43881.]
    Type of Medium: Online Resource
    ISSN: 0001-4966 , 1520-8524
    URL: Article
    DOI: 10.1121/1.4831463
    RVK:
    EQ 1000
    Language: English
    Publisher: Acoustical Society of America (ASA)
    Publication Date: 2013
    detail.hit.zdb_id: 1461063-2
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  • 5
    Online Resource
    Online Resource
    Low-energy shock wave pretreatment results in greater vasoconstriction and less injury in the kidney compared to high-energy shock wave lithotripsy treatment alone.
    Acoustical Society of America (ASA) ; 2009
    In:  The Journal of the Acoustical Society of America Vol. 125, No. 4_Supplement ( 2009-04-01), p. 2621-2621
    Details
    In: The Journal of the Acoustical Society of America, Acoustical Society of America (ASA), Vol. 125, No. 4_Supplement ( 2009-04-01), p. 2621-2621
    Abstract: Pretreating the kidney with low-energy shock waves (SWs) before administering a clinical dose of high-energy SWs has been found to greatly decrease the hemorrhagic lesion that normally results from high-energy shock wave lithotripsy (SWL) treatment alone. We tested the hypothesis that this novel pretreatment SWL protocol results in a greater and/or earlier renal vasoconstriction than clinical SWL alone, which could potentially explain the reduced bleeding in the kidney. Anesthetized pigs were treated with a clinical dose of SWs (2000 SWs, 24 kV, 120 SWs/min) or the pretreatment protocol (500 SWs, 12 kV, 120 SWs/min + 3-min pause + 2000 SWs, 24 kV, 120 SWs/min) using the HM3 lithotripter. Sonography (color and pulsed ultrasound) was used to locate a resistance artery within the SW-treated pole of the kidney and to take resistance index (RI) measurements from the blood vessel to estimate the resistance/impedance to blood flow. The results demonstrated that RI increased (renal vasoconstriction) earlier and greater during the pretreatment protocol compared to normal clinical SWL. Constricted blood vessels would likely be less prone to rupture by SWs and, if broken, would bleed less—resulting in a smaller hemorrhagic lesion.
    Type of Medium: Online Resource
    ISSN: 0001-4966 , 1520-8524
    URL: Article
    DOI: 10.1121/1.4783985
    RVK:
    EQ 1000
    Language: English
    Publisher: Acoustical Society of America (ASA)
    Publication Date: 2009
    detail.hit.zdb_id: 1461063-2
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  • 6
    Online Resource
    Online Resource
    Shock wave lithotripsy can alter urinary acid-base pH regulation.
    Acoustical Society of America (ASA) ; 2009
    In:  The Journal of the Acoustical Society of America Vol. 125, No. 4_Supplement ( 2009-04-01), p. 2622-2622
    Details
    In: The Journal of the Acoustical Society of America, Acoustical Society of America (ASA), Vol. 125, No. 4_Supplement ( 2009-04-01), p. 2622-2622
    Abstract: The renal papilla is particularly susceptible to injury by shock waves (SWs). Since the papilla is vital for urinary pH regulation, we hypothesized that shock wave lithotripsy (SWL)-induced damage of papillae will alter the pH of the urine. Experiments were conducted in four female adult Gottingen minipigs. The HM3 lithotripter delivered a total of 8000 SWs (24 kV, 120 SWs/min) among all papillae of one kidney, while the untreated, opposite kidney was used as control. The pigs were allowed to recover and 5 weeks later they were anesthetized. Serial urine collections were obtained from the SW-treated and untreated kidney. Urine was collected under mineral oil and immediately tested for its pH. Both kidneys were then perfusion fixed for histological analysis. Urinary pH was 0.17 units greater (P & lt;0.05) in the SW-treated kidney compared to the untreated kidney. Histology showed scarring in all regions of the SW-treated kidney, with thick ascending limbs and collecting ducts having grossly abnormal morphologies indicative of cellular proliferation. These results suggest that SWL-induced injury can cause remodeling of nephron structures and long-term impairment in the regulation of urinary pH.
    Type of Medium: Online Resource
    ISSN: 0001-4966 , 1520-8524
    URL: Article
    DOI: 10.1121/1.4783992
    RVK:
    EQ 1000
    Language: English
    Publisher: Acoustical Society of America (ASA)
    Publication Date: 2009
    detail.hit.zdb_id: 1461063-2
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