In:
Clay Minerals, Mineralogical Society, Vol. 22, No. 2 ( 1987-06), p. 121-128
Abstract:
The interaction of montmorillonite with sotalol hydrochloride (4-(1-hydroxy- N -isopropylaminoethyl) methane sulfanilide) was studied by means of adsorption isotherms, XRD and IR spectroscopy. The amount of sotalol adsorbed depended on pH, the maximum amount adsorbed (0·56 mEq g −1 ) being considerably less than the exchange capacity of the mineral (0·80 mEq g −1 ). XRD and IR data revealed that the sotalol is adsorbed into the interlayer space, forming a monolayer complex with a d 001 spacing of 17·7 Å, and that the mechanisms involved are cation exchange and ion-dipole interactions. Experiments on the in vitro desorption of the drug from the sotalol-montmorillonite complex indicated that desorption is affected by pH, by the salt concentration of the electrolyte, and by the elimination rate of the desorbed organic cations.
Type of Medium:
Online Resource
ISSN:
0009-8558
,
1471-8030
DOI:
10.1180/claymin.1987.022.2.01
Language:
English
Publisher:
Mineralogical Society
Publication Date:
1987
detail.hit.zdb_id:
2036186-5
detail.hit.zdb_id:
961059-5
SSG:
13
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