In:
Synlett, Georg Thieme Verlag KG, Vol. 32, No. 19 ( 2021-12), p. 1974-1980
Abstract:
Promoted by K2CO3 (2.0 equiv), the 1,3-dipolar [3+3] cycloaddition between 1, 4-benzodiazepinone-based nitrones and α-halohydroxamates processed smoothly under the mild reaction conditions and delivered structurally novel and complex cis- or trans-configured d-edge heterocycle-fused 1,4-benzodiazepinones in up to 〉 99% isolated yield with 〉 20:1 dr. The relative configuration of the title chemical entities was clearly identified with the use of single-crystal X-ray structure analysis. The reaction mechanism was assumed to interpret the diastereoselective production of the obtained cis- or trans-configured d-edge heterocycle-fused 1,4-benzodiazepinones.
Type of Medium:
Online Resource
ISSN:
0936-5214
,
1437-2096
Language:
English
Publisher:
Georg Thieme Verlag KG
Publication Date:
2021
detail.hit.zdb_id:
2042012-2
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