In:
Angewandte Chemie, Wiley, Vol. 131, No. 9 ( 2019-02-25), p. 2910-2914
Abstract:
A palladium‐catalyzed asymmetric reductive Heck reaction of unactivated aliphatic alkenes, with eliminable β‐hydrogen atoms, has been realized for the first time. A series of optically active bicyclo[3.2.1]octanes bearing chiral quaternary and tertiary carbon stereocenters were obtained in good yields with excellent enantioselectivities, exhibiting good functional‐group tolerance and scalability. Moreover, deuterated optically active bicyclo[3.2.1] octanes were also obtained in high efficiency.
Type of Medium:
Online Resource
ISSN:
0044-8249
,
1521-3757
DOI:
10.1002/ange.201900059
Language:
English
Publisher:
Wiley
Publication Date:
2019
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505868-5
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514305-6
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505872-7
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1479266-7
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505867-3
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506259-7
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