In:
Angewandte Chemie, Wiley, Vol. 133, No. 3 ( 2021-01-18), p. 1247-1254
Abstract:
Glutathione peroxidase (GPx) plays an important role in maintaining the reactive oxygen metabolic balance, yet limited GPx‐mimicking nanozymes are currently available for in vivo therapy. Herein, a ligand engineering strategy is developed to modulate the GPx‐mimicking activity of a metal–organic framework (MOF) nanozyme. With different substituted ligands, the GPx‐mimicking activities of MIL‐47(V)‐X (MIL stands for Materials of Institute Lavoisier; X=F, Br, NH 2 , CH 3 , OH, and H) MOFs are rationally regulated. With the best one as an example, both in vitro and in vivo experiments reveal the excellent antioxidation ability of MIL‐47(V)‐NH 2 , which alleviates the inflammatory response effectively for both ear injury and colitis, and is more active than MIL‐47(V). This study proves that high‐performance GPx‐mimicking nanozymes can be rationally designed by a ligand engineering strategy, and that structure–activity relationships can direct the in vivo therapy. This study enriches nanozyme research and expands the range of biomimetic MOFs.
Type of Medium:
Online Resource
ISSN:
0044-8249
,
1521-3757
DOI:
10.1002/ange.202010714
Language:
English
Publisher:
Wiley
Publication Date:
2021
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