In:
Synthesis, Georg Thieme Verlag KG, Vol. 52, No. 02 ( 2020-01), p. 197-207
Abstract:
The difluoromethylthio group (HCF2S), which has been identified as a valuable functionality in drug and agrochemical discovery, has received increased attention recently. Two strategies, difluoromethylation and direct difluoromethylthiolation, have been well established for HCF2S incorporation. The former strategy suffers from the need to prepare sulfur-containing substrates. In contrast, direct difluoromethylthiolation is straightforward and step-economic. This short review covers the recent advances in direct difluoromethylthiolation, including electrophilic, radical, and transition-metal-catalyzed or -promoted reactions. 1 Introduction 2 Electrophilic Difluoromethylthiolation 3 Radical Difluoromethylthiolation 4 Transition-Metal-Catalyzed or -Promoted Difluoromethylthiolation 5 Conclusions and Perspectives
Type of Medium:
Online Resource
ISSN:
0039-7881
,
1437-210X
DOI:
10.1055/s-0039-1690714
Language:
English
Publisher:
Georg Thieme Verlag KG
Publication Date:
2020
detail.hit.zdb_id:
204080-3
detail.hit.zdb_id:
2033062-5
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