In:
Helvetica Chimica Acta, Wiley, Vol. 99, No. 9 ( 2016-09), p. 681-686
Abstract:
Using various chromatographic methods, three new megastigmane glycosides, docynicasides A – C ( 1 – 3 ) and ten known, (6 S ,9 R )‐vomifoliol 9‐ O ‐ β ‐ d ‐xylopyranosyl‐(1′′→6′)‐ O ‐ β ‐ d ‐glucopyranoside ( 4 ), hyperin ( 5 ), quercitrin ( 6 ), quercetin 3‐ α ‐ l ‐arabinofuranoside ( 7 ), naringenin 7‐ O ‐ β ‐ d ‐glucopyranoside ( 8 ), phloridzin ( 9 ), phloretin 2′‐ O ‐ β ‐ d ‐xylopyranosyl‐(1→6)‐ β ‐ d ‐glucopyranoside ( 10 ), pinosylvin 3‐ O ‐ β ‐ d ‐glucopyranoside ( 11 ), tormentic acid ( 12 ), and chlorogenic acid methyl ester ( 13 ) were isolated from the fruits of Docynia indica . Their chemical structures were elucidated by physical and chemical methods. All the isolated compounds were evaluated for the inhibitory activity on NO production in LPS ‐stimulated BV 2 cells. As the results, compounds 3 – 5 showed significant inhibitory activity on LPS ‐stimulated NO production in BV 2 cells with the IC 50 values ranging from 21.0 to 29.3 μ m .
Type of Medium:
Online Resource
ISSN:
0018-019X
,
1522-2675
DOI:
10.1002/hlca.201600125
Language:
English
Publisher:
Wiley
Publication Date:
2016
detail.hit.zdb_id:
74-7
detail.hit.zdb_id:
1475013-2
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