In:
Chemistry – A European Journal, Wiley, Vol. 11, No. 5 ( 2005-02-18), p. 1507-1517
Abstract:
[Ru(hat) 2 phen] 2+ (HAT=1,4,5,8,9,12‐hexaazatriphenylene, phen=1,10‐phenanthroline) interacts with a good affinity with polynucleotides and DNA by intercalation, despite the presence of a second voluminous ancillary HAT ligand. It photoreacts with guanosine‐5′‐monophosphate (GMP). From HPLC, ESMS and NMR analyses, it can be concluded that this complex forms photoadducts with GMP. In contrast to the photoadducts isolated with Ru–TAP complexes (TAP=1,4,5,8‐tetraazaphenanthrene), the photoadducts with [Ru(hat) 2 phen] 2+ contain a covalent link between the oxygen atom of the guanine unit and a HAT ligand. Formation of oxidised photoadducts and compounds resulting from the addition of two GMP entities to the complex are also detected as side products. In the presence of oligo‐ and polynucleotides, [Ru(hat) 2 phen] 2+ yields photoadducts when guanine bases are present.
Type of Medium:
Online Resource
ISSN:
0947-6539
,
1521-3765
DOI:
10.1002/chem.200400591
Language:
English
Publisher:
Wiley
Publication Date:
2005
detail.hit.zdb_id:
1478547-X
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