In:
Journal of the American Ceramic Society, Wiley, Vol. 106, No. 12 ( 2023-12), p. 7218-7229
Abstract:
The design and optimization of nanostructures with unique morphologies and properties are at the forefront of biomedical nanotechnology. Cerium oxides are widely used to investigate the effect of morphology on performance. However, elucidating the morphology–activity relationship of cerium oxide nanocrystals in biomedical applications remains challenging. Herein, the therapeutic effects of cerium oxide nanoparticles with different morphologies: cerium oxide nanorods with two different aspect ratios (CeO x NRs_A and CeO x NRs_B), cerium oxide nanopolyhedra (CeO x NPs), and cerium oxide nanocubes (CeO x NCs) are investigated in in vivo and in vitro mild traumatic brain injury (TBI) models. Cerium oxide nanoparticles inhibit oxidative stress and inflammation after mild TBI, alleviating cognitive impairment; furthermore, the therapeutic effect is significantly affected by their morphology. Owing to the higher Ce 3+ /Ce 4+ ratio, exposure of more active crystal surfaces, and greater number of exposed oxygen vacancies, CeO x NRs show better activity than CeO x NPs and CeO x NCs for mild TBI. Among the two investigated types of cerium oxide nanorods, CeO x NRs_A, with a higher Ce 3+ /Ce 4+ ratio on the surface, appear to spread better than CeO x NRs_B in the injured lesions. The factors causing morphology‐controlled biomedical performance, such as Ce 3+ /Ce 4+ molar ratio, surface area, and aspect ratio, are discussed.
Type of Medium:
Online Resource
ISSN:
0002-7820
,
1551-2916
DOI:
10.1111/jace.v106.12
Language:
English
Publisher:
Wiley
Publication Date:
2023
detail.hit.zdb_id:
2008170-4
detail.hit.zdb_id:
219232-9
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