In:
Chemistry – A European Journal, Wiley, Vol. 21, No. 46 ( 2015-11-09), p. 16400-16403
Abstract:
The total synthesis of (−)‐isoschizogamine was accomplished, featuring the construction of the quaternary carbon center by the modified Johnson–Claisen rearrangement in basic media and the facile assembly of the key tetracyclic quinolone intermediate through a cascade cyclization. The characteristic cyclic aminal was constructed by late‐stage CH functionalization at the position adjacent to the lactam nitrogen using a combination of CrO 3 and n Bu 4 NIO 4 and subsequent Bi(OTf) 3 ‐mediated cyclization.
Type of Medium:
Online Resource
ISSN:
0947-6539
,
1521-3765
DOI:
10.1002/chem.201503606
Language:
English
Publisher:
Wiley
Publication Date:
2015
detail.hit.zdb_id:
1478547-X
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