In:
European Journal of Inorganic Chemistry, Wiley, Vol. 2013, No. 16 ( 2013-06), p. 2858-2866
Abstract:
To date, only a few nanosystems have been investigated as T 1 MRI‐CT dual contrast agents. The T 1 MRI‐CT dual functionality of a material depends on its longitudinal water‐proton relaxivity ( r 1 ) and X‐ray absorption strength. We explored Gd(IO 3 ) 3 · 2H 2 O nanomaterial because Gd is the most powerful element for T 1 MRI contrast agents, and both Gd and I absorb X‐ray radiation; Gd absorbs X‐ray radiation ca. 2.5 times more strongly than I. D ‐Glucuronic acid coated Gd(IO 3 ) 3 · 2H 2 O nanomaterial showed a very large r 1 of 52.3 s –1 m M –1 ( r 2 / r 1 = 1.21), which could be ascribed to hydrated water molecules in the lattice. Its X‐ray absorption intensity was also stronger than those of commercial molecular iodine CT contrast agents. This result clearly suggests that D ‐glucuronic acid coated Gd(IO 3 ) 3 · 2H 2 O nanomaterial is a potential T 1 MRI‐CT dual contrast agent.
Type of Medium:
Online Resource
ISSN:
1434-1948
,
1099-0682
DOI:
10.1002/ejic.v2013.16
DOI:
10.1002/ejic.201201481
Language:
English
Publisher:
Wiley
Publication Date:
2013
detail.hit.zdb_id:
1475009-0
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