In:
European Journal of Organic Chemistry, Wiley, Vol. 26, No. 12 ( 2023-03-21)
Abstract:
An asymmetric Friedel–Crafts alkylation of indole with in situ generated indol‐2‐one from functionalized 3‐bromooxinidole catalyzed by chiral N,N’ ‐dioxide/Ni(BF 4 ) 2 has been developed. This protocol provides an efficient route to stereoselective construction of a series of 3‐substituted 3’‐indolyloxindoles bearing a quaternary carbon center in excellent yields and enantioselectivities (up to 99 % ee). In addition, the conversion of the resulted 3‐substituted 3’‐indolyloxindole to the key intermediate for the formal synthesis of (+)‐folicanthine was also demonstrated.
Type of Medium:
Online Resource
ISSN:
1434-193X
,
1099-0690
DOI:
10.1002/ejoc.202300122
Language:
English
Publisher:
Wiley
Publication Date:
2023
detail.hit.zdb_id:
1475010-7
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