In:
European Journal of Organic Chemistry, Wiley, Vol. 2003, No. 22 ( 2003-11), p. 4438-4444
Abstract:
We have employed high‐intensity ultrasound (HIU) to reinvestigate the aldol reaction (AR) in water. A number of aldols that under usual conditions would undergo elimination were isolated in acceptable to good yields. Within 15−30 min, acetophenone reacted with non‐enolizable aldehydes to afford the aldol exclusively, while under conventional conditions (stirring or heating under reflux) the same compounds either failed to react or gave, after several hours, the enone, often in complex product mixtures. A library of polyols was obtained starting from a series of acetophenones and excess formaldehyde. Benzaldehyde reacted with a series of 1,3‐dicarbonyl compounds to afford the corresponding bis(benzylidene) adducts. The results proved to be highly reproducible because the relevant sonochemical parameters were rigorously controlled. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003)
Type of Medium:
Online Resource
ISSN:
1434-193X
,
1099-0690
DOI:
10.1002/ejoc.v2003:22
DOI:
10.1002/ejoc.200300369
Language:
English
Publisher:
Wiley
Publication Date:
2003
detail.hit.zdb_id:
1475010-7
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