In:
Angewandte Chemie, Wiley, Vol. 130, No. 47 ( 2018-11-19), p. 15686-15690
Abstract:
Reported is a tandem palladium‐catalyzed Heck/regioselective C(sp 3 )−H activation reaction for the divergent synthesis of spiro‐ and fused‐cyclopropanated indolines from N ‐methallylated 2‐bromoarylamides. The regioselectivity of the C−H bond activation in the σ‐alkylPd II intermediate is controlled by the solvent used. DFT calculations suggest that the polarity of solvent molecules could influence the transition‐state energy, leading to a bifurcation of the C−H bond activation in the σ‐alkylPd II intermediate.
Type of Medium:
Online Resource
ISSN:
0044-8249
,
1521-3757
DOI:
10.1002/ange.v130.47
DOI:
10.1002/ange.201809133
Language:
English
Publisher:
Wiley
Publication Date:
2018
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505868-5
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514305-6
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505872-7
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1479266-7
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505867-3
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506259-7
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