In:
European Journal of Organic Chemistry, Wiley, Vol. 2005, No. 19 ( 2005-10), p. 4065-4072
Abstract:
Demethylthio‐, S ‐demethyl‐, and S ‐ethyl derivatives of the α‐mannosidase inhibitor, mannostasin A, were synthesized and evaluated for their inhibition of Jack bean α‐mannosidase with the prime objective of elucidating the role of the methylthio group. All methylthio derivatives had significantly lowered inhibitory potentials. However, one mannostatin A analogue with a methoxyl instead of the methylthio group exhibited about twofold enhancement of the activity. The structure and inhibitory activity relationships of mannostatin A and related compounds are discussed in light of our results. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)
Type of Medium:
Online Resource
ISSN:
1434-193X
,
1099-0690
DOI:
10.1002/ejoc.v2005:19
DOI:
10.1002/ejoc.200500118
Language:
English
Publisher:
Wiley
Publication Date:
2005
detail.hit.zdb_id:
1475010-7
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