In:
European Journal of Organic Chemistry, Wiley, Vol. 2015, No. 13 ( 2015-05), p. 2965-2971
Abstract:
An interesting class of heterocyclic compounds, 1,2,4‐oxadiazoles and their derivatives have attracted the attention of chemists because of their use in the development of new pharmaceuticals and functional materials. Herein, a catalyst‐free reaction of N ‐hydroxyamidoxime with various ketones or aldehydes has been investigated. The reaction was carried out in methanol under mild conditions and gave 3,5,5‐trisubstituted 4‐hydroxy‐4 H ,5 H ‐1,2,4‐oxadiazole derivatives in excellent yields. The structure of product 3f was confirmed by single‐crystal X‐ray diffraction studies.
Type of Medium:
Online Resource
ISSN:
1434-193X
,
1099-0690
DOI:
10.1002/ejoc.v2015.13
DOI:
10.1002/ejoc.201500083
Language:
English
Publisher:
Wiley
Publication Date:
2015
detail.hit.zdb_id:
1475010-7
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