In:
Angewandte Chemie, Wiley, Vol. 131, No. 15 ( 2019-04), p. 5082-5086
Abstract:
N 6 ‐Methyladenosine (m 6 A) represents a common and highly dynamic modification in eukaryotic RNA that affects various cellular pathways. Natural dioxygenases such as FTO and ALKBH5 are enzymes that demethylate m 6 A residues in mRNA. Herein, the first identification of a small‐molecule modulator that functions as an artificial m 6 A demethylase is reported. Flavin mononucleotide (FMN), the metabolite produced by riboflavin kinase, mediates substantial photochemical demethylation of m 6 A residues of RNA in live cells. This study provides a new perspective to the understanding of demethylation of m 6 A residues in mRNA and sheds light on the development of powerful small molecules as RNA demethylases and new probes for use in RNA biology.
Type of Medium:
Online Resource
ISSN:
0044-8249
,
1521-3757
DOI:
10.1002/ange.v131.15
DOI:
10.1002/ange.201900901
Language:
English
Publisher:
Wiley
Publication Date:
2019
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514305-6
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505872-7
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1479266-7
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