In:
Chemistry – A European Journal, Wiley, Vol. 29, No. 36 ( 2023-06-27)
Abstract:
The incorporation of the privileged amino functionality is of paramount importance in organic synthesis. In contrast to the well‐developed amination methods for alkenes, the dearomative amination of arenes is largely underexplored due to the inherently inert reactivity of arene π‐bonds and selectivity challenges. Herein, we report an intermolecular dearomative aminofunctionalization via direct nucleophilic addition of simple amines to chromium‐bound arenes. This multicomponent 1,2‐amination/carbonylation reaction enables rapid access to complicated alicyclic compounds containing amino and amide functionalities from benzene derivatives under CO‐gas‐free conditions, which also represents the first application of nitrogen‐based nucleophiles in η 6 ‐coordination‐induced arene dearomatizations.
Type of Medium:
Online Resource
ISSN:
0947-6539
,
1521-3765
DOI:
10.1002/chem.202300776
Language:
English
Publisher:
Wiley
Publication Date:
2023
detail.hit.zdb_id:
1478547-X
Permalink