In:
Chemistry – A European Journal, Wiley, Vol. 24, No. 16 ( 2018-03-15), p. 4111-4120
Abstract:
Photodynamic therapy (PDT) is a promising and minimally invasive method for the treatment of superficial diseases, and photosensitizers with high phototoxicity indices (defined as (IC 50 dark )/(IC 50 irradiation )) are essential for the development of ideal photosensitizing properties for this technology. Herein, we report a series of photocytotoxic copper(II) complexes [Cu( R QYMP )(dppn)] ( R QYMP = N , N , O ‐tridentate Schiff‐base derivatives, dppn=benzo[ i ]dipyrido[3,2‐ a ;2′,3′‐ c ]phenazine), the structures of which have been confirmed by mass spectrometry and FTIR spectroscopy. X‐ray crystallography revealed that the CuN 4 O core of the [Cu( cumyl QYMP )(dppn)](ClO 4 ) complex ( 3 ) has a distorted square‐pyramidal geometry. Phototoxicity indices of 329 against human squamous cell carcinoma (SCC15) and 296 against basal cell carcinoma (BCC) cell lines have been determined with [Cu( 3‐OMe QYMP )(dppn)](ClO 4 ) ( 4 ). This can be attributed to the formation of reactive oxygen species, cell apoptosis, and caspase‐3 activation, indicating high potential of complex 4 as a photosensitizer candidate in PDT. Thus, copper complexes bearing suitable Schiff‐base ligands with a dppn co‐ligand may be considered for the design of efficient metal‐based anticancer agents for PDT.
Type of Medium:
Online Resource
ISSN:
0947-6539
,
1521-3765
DOI:
10.1002/chem.201705640
Language:
English
Publisher:
Wiley
Publication Date:
2018
detail.hit.zdb_id:
1478547-X
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