In:
Chemistry Letters, Oxford University Press (OUP), Vol. 19, No. 4 ( 1990-04-01), p. 505-508
Abstract:
We describe an efficient synthesis of highly active renin inhibitors containing a sulfonemethylene isostere at their N-terminals and a hydroxyethylene isostere at their C-terminals. The stereospecific synthesis of N-terminal key intermediate, L-N-[(2R)-2-benzyl(or 1-naphthylmethyl)-3-hydroxypropionyl]norleucine t-butyl ester is described.
Type of Medium:
Online Resource
ISSN:
0366-7022
,
1348-0715
Language:
English
Publisher:
Oxford University Press (OUP)
Publication Date:
1990
detail.hit.zdb_id:
2063626-X
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