In:
Angewandte Chemie, Wiley, Vol. 128, No. 33 ( 2016-08-08), p. 9842-9846
Abstract:
Reported herein is an unprecedented base‐promoted deborylative alkylation of pyridine N‐oxides using 1,1‐diborylalkanes as alkyl sources. The reaction proceeds efficiently for a wide range of pyridine N‐oxides and 1,1‐diborylalkanes with excellent regioselectivity. The utility of the developed method is demonstrated by the sequential C−H arylation and methylation of pyridine N‐oxides. The reaction also can be applied for the direct introduction of a methyl group to 9‐O‐methylquinine N‐oxide, thus it can serve as a powerful method for late‐stage functionalization.
Type of Medium:
Online Resource
ISSN:
0044-8249
,
1521-3757
DOI:
10.1002/ange.v128.33
DOI:
10.1002/ange.201603329
Language:
English
Publisher:
Wiley
Publication Date:
2016
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505868-5
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514305-6
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505872-7
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1479266-7
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505867-3
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506259-7
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