In:
Australian Journal of Chemistry, CSIRO Publishing, Vol. 74, No. 6 ( 2021-2-1), p. 443-452
Abstract:
We successfully radiolabelled a novel prospective cannabinoid type 2 receptor ligand with 18F and tested its biodistribution in animal models by positron emission tomography (PET)/computed tomography (CT) imaging. The radiolabelling process was conducted on an alkyl mesylate fragment of the main naphthyridine core, using highly efficient microfluidic technology. No preliminary protection was needed, and the product was purified by semi-prep HPLC and SPE formulation, allowing the desired diastereomeric mixture to be obtained in 29 % radiochemical yield and 〉 95 % radiochemically pure. SOD1G93A mice were used as model of overexpression of CB2 receptors; PET imaging revealed a significant increase of the tracer distribution volume in the brain of symptomatic subjects compared with the asymptomatic ones.
Type of Medium:
Online Resource
ISSN:
0004-9425
,
1445-0038
Language:
English
Publisher:
CSIRO Publishing
Publication Date:
2021
Permalink