In:
Angewandte Chemie, Wiley, Vol. 129, No. 21 ( 2017-05-15), p. 5947-5951
Abstract:
Spiro[4,5]decanes and polycyclic compounds bearing spiro[4,5] decane systems are important biofunctional molecules. Described are diastereoselective formal (4+1) cycloaddition reactions to afford oxindole‐functionalized spiro[4,5]decanes and organocatalytic enantioselective Michael–Henry cascade reactions of the (4+1) cycloaddition products to generate spirooxindole polycyclic derivatives bearing the spiro[4,5] decane system. Spiro[4,5]decanes bearing oxindoles containing three stereogenic centers and spirooxindole polycycles having seven stereogenic centers, including two all‐carbon chiral quaternary centers and one tetrasubstituted chiral carbon center, were obtained with high diastereo‐ and enantioselectivities.
Type of Medium:
Online Resource
ISSN:
0044-8249
,
1521-3757
DOI:
10.1002/ange.v129.21
DOI:
10.1002/ange.201701049
Language:
English
Publisher:
Wiley
Publication Date:
2017
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505872-7
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1479266-7
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