In:
European Journal of Organic Chemistry, Wiley, Vol. 2007, No. 21 ( 2007-07), p. 3555-3563
Abstract:
tert ‐Butyl hydroperoxide catalyzed by ( meso ‐5,10,15,20‐tetramesitylporphyrinate)osmium(II) carbonyl [Os(TMP)CO] was shown to be an efficient, versatile oxyfunctionalization system for the methyl ester peracetate derivatives of a series of common, natural (5β)‐bile acids. Hydroxylation at C‐5 and C‐14, ketonization at C‐15 and C‐16, and isomerization at C‐5 and C‐14 in the nucleus were all attained in one step. Factors governing the regioselectivity as well as the mechanism of formation of these compounds are discussed.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)
Type of Medium:
Online Resource
ISSN:
1434-193X
,
1099-0690
DOI:
10.1002/ejoc.v2007:21
DOI:
10.1002/ejoc.200700158
Language:
English
Publisher:
Wiley
Publication Date:
2007
detail.hit.zdb_id:
1475010-7
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