In:
Journal of Heterocyclic Chemistry, Wiley, Vol. 53, No. 6 ( 2016-11), p. 2007-2012
Abstract:
The reaction of 5‐amino‐3‐methylisoxazole ( 1 ) with aldimines 2 , 3 , 4 , 5 , 6 , 7 gave basic side chain 5‐amino‐3‐methylisoxazole derivatives 8 , 9 , 10 , 11 , 12 , 13 . Annulations of derivatives 8 , 9 , 10 , 11 , 12 , 13 with anisaldehyde afforded the target isoxazolo[5,4‐ d ]pyrimidines 14 , 15 , 16 , 17 . Treatment of 1 with isatin ketimine anil 18 resulted in the formation of derivative 19 , which further cyclized with anisaldehyde afforded the spirotetracyclic system 20 . Mannich reaction of 1 with primary amine such as methylamine and benzylamine gave the corresponding isoxazolo[5,4‐d]pyrimidine derivatives 21 and 22 , respectively. The newly synthesized compounds were tested for their antitumor activity.
Type of Medium:
Online Resource
ISSN:
0022-152X
,
1943-5193
Language:
English
Publisher:
Wiley
Publication Date:
2016
detail.hit.zdb_id:
2042274-X
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