In:
Chemistry – A European Journal, Wiley, Vol. 26, No. 56 ( 2020-10-06), p. 12839-12845
Abstract:
A simple and efficient way to synthesize peptide‐containing silicone materials is described. Silicone oils containing a chosen ratio of bioactive peptide sequences were prepared by acid‐catalyzed copolymerization of dichlorodimethylsilane, hybrid dichloromethyl peptidosilane, and Si(vinyl)‐ or SiH‐functionalized monomers. Functionalized silicone oils were first obtained and then, after hydrosilylation cross‐linking, bioactive polydimethylsiloxane (PDMS)‐based materials were straightforwardly obtained. The introduction of an antibacterial peptide yielded PDMS materials showing activity against Staphylococcus aureus . PDMS containing RGD ligands showed improved cell‐adhesion properties. This generic method was fully compatible with the stability of peptides and thus opened the way to the synthesis of a wide range of biologically active silicones.
Type of Medium:
Online Resource
ISSN:
0947-6539
,
1521-3765
DOI:
10.1002/chem.202001571
Language:
English
Publisher:
Wiley
Publication Date:
2020
detail.hit.zdb_id:
1478547-X
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