In:
Chemistry – A European Journal, Wiley, Vol. 20, No. 35 ( 2014-08-25), p. 11048-11057
Abstract:
The N , N ′‐bis[(3‐hydroxy‐4‐pyron‐2‐yl)methyl]‐ N , N ′‐dimethylethylendiamine (Malten= L ) forms the highly stable [CuH −2 L ] species in water, in which the converging maltol oxygen atoms form an electron‐rich area able to host hard metal ions. When considering the alkaline earth series (AE), the [Cu(H −2 L )] species binds all metal ions, with the exception of Mg 2+ , exhibiting the relevant property to discriminate Ca 2+ versus Mg 2+ at physiological pH 7.4; the binding of the AE metal is visible to the naked eye. The stability constant values of the trinuclear [AE{Cu(H −2 L )} 2 ] 2+ species formed reach the maximum for Ca 2+ (log K =7.7). Ca 2+ also forms a tetranuclear [Ca{Cu(H −2 L )}] 2 4+ species at a high Ca 2+ concentration. Tri‐ and tetranuclear calcium complexes show blue‐ and pink‐colored crystals, respectively. [Cu(H −2 L )] is the most active species in inducing DNA alterations. The DNA damages are compatible with its hydrolytic cleavages.
Type of Medium:
Online Resource
ISSN:
0947-6539
,
1521-3765
DOI:
10.1002/chem.201403084
Language:
English
Publisher:
Wiley
Publication Date:
2014
detail.hit.zdb_id:
1478547-X
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