In:
Angewandte Chemie, Wiley, Vol. 130, No. 40 ( 2018-10), p. 13314-13318
Abstract:
Intermolecular asymmetric gold catalysis involving alkyne activation presents a significant challenge due to its distinct mechanistic mode from other metals. Herein, we report a highly enantioselective synthesis of α,β‐unsaturated δ‐lactones from [4+2] annulation of propiolates and alkenes in upto 95 % ee . Notably, for the desired chiral recognition, the choice of 1,1,2,2‐tetrachloroethane as solvent was found to be crucial. Furthermore, an anionic surfactant (sodium dodecyl sulfate) improved the product selectivity in the divergence of the cyclopropyl gold carbene intermediate.
Type of Medium:
Online Resource
ISSN:
0044-8249
,
1521-3757
DOI:
10.1002/ange.v130.40
DOI:
10.1002/ange.201807514
Language:
English
Publisher:
Wiley
Publication Date:
2018
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505868-5
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506609-8
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514305-6
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505872-7
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1479266-7
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505867-3
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506259-7
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