In:
Angewandte Chemie, Wiley, Vol. 135, No. 17 ( 2023-04-17)
Abstract:
Represented herein is the first example of N ‐radical generation direct from N −H bond activation under mild and redox‐neutral conditions. The in situ generated N ‐radical intercepts a reduced heteroarylnitrile/aryl halide for C−N bond formation under visible‐light irradiation of quantum dots (QDs). A series of aryl and alkylamines with heteroarylnitriles/aryl halides exhibit high efficiency, site‐selectivity and good functional‐group tolerance. Moreover, consecutive C−C and C−N bond formation using benzylamines as substrates is also achieved, producing N ‐aryl‐1,2‐diamines with H 2 evolution. The redox‐neutral conditions, broad substrate scope, and efficiency of N ‐radical formation are advantageous for organic synthesis.
Type of Medium:
Online Resource
ISSN:
0044-8249
,
1521-3757
DOI:
10.1002/ange.v135.17
DOI:
10.1002/ange.202218391
Language:
English
Publisher:
Wiley
Publication Date:
2023
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