In:
Angewandte Chemie, Wiley, Vol. 128, No. 40 ( 2016-09-26), p. 12416-12420
Abstract:
A highly efficient asymmetric ring‐opening/cyclization/retro‐Mannich reaction of cyclopropyl ketones with aryl 1,2‐diamines has been realized using a chiral N , N′ ‐dioxide/Sc III catalyst. Benzimidazoles containing chiral side chains were generated under mild reaction conditions in excellent outcomes (up to 99 % yield and 97 % ee ). This method also provides efficient access to chiral benzimidazole‐substituted amide and cycloheptene derivatives.
Type of Medium:
Online Resource
ISSN:
0044-8249
,
1521-3757
DOI:
10.1002/ange.v128.40
DOI:
10.1002/ange.201604735
Language:
English
Publisher:
Wiley
Publication Date:
2016
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506609-8
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514305-6
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505872-7
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1479266-7
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505867-3
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506259-7
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