In:
European Journal of Inorganic Chemistry, Wiley, Vol. 2010, No. 28 ( 2010-10), p. 4555-4560
Abstract:
We have developed ultra‐small gadolinium oxide (Gd 2 O 3 ) nanoparticles, which are surface‐doped with manganese oxide (MnO) (abbreviated as Gd 2 O 3 @MnO). The surface‐doped nanoparticles ranged from 1 to 2 nm in diameter. They were further coated with hydrophilic biocompatible lactobionic acid. In‐vitro tests of the sample solution indicated clear dose‐dependent contrast enhancements in both T 1 and T 2 map images, showing that the nanoparticles may be used as both T 1 and T 2 MRI contrast agents. Their performance as a T 1 MRI contrast agent was proved in vivo through T 1 MR images of a mouse.
Type of Medium:
Online Resource
ISSN:
1434-1948
,
1099-0682
DOI:
10.1002/ejic.v2010:28
DOI:
10.1002/ejic.201000374
Language:
English
Publisher:
Wiley
Publication Date:
2010
detail.hit.zdb_id:
1475009-0
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