In:
Annual Review of Pharmacology and Toxicology, Annual Reviews, Vol. 40, No. 1 ( 2000-04), p. 491-518
Abstract:
Peroxisome proliferators (PPs) are a large class of structurally dissimilar chemicals that have diverse effects in rodents and humans. Most, if not all, of the diverse effects of PPs are mediated by three members of the nuclear receptor superfamily called peroxisome proliferator-activated receptors (PPARs). In this review, we define the molecular mechanisms of PPs, including PPAR binding specificity, alteration of gene expression through binding to DNA response elements, and cross talk with other signaling pathways. We discuss the roles of PPARs in growth promotion in rodent hepatocarcinogenesis and potential therapeutic effects, including suppression of cancer growth and inflammation.
Type of Medium:
Online Resource
ISSN:
0362-1642
,
1545-4304
DOI:
10.1146/pharmtox.2000.40.issue-1
DOI:
10.1146/annurev.pharmtox.40.1.491
Language:
English
Publisher:
Annual Reviews
Publication Date:
2000
detail.hit.zdb_id:
1474461-2
SSG:
15,3
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