In:
ChemMedChem, Wiley, Vol. 10, No. 8 ( 2015-08), p. 1403-1412
Abstract:
In this study, a series of new 4,4′‐diaminotriphenylmethanes was efficiently synthesized from aromatic aldehydes and 2,5‐dimethoxybenzenamine under microwave irradiation in the presence of Sc(OTf) 3 as a catalyst. Antiproliferative activity was assessed by using the MCF‐7 estrogen receptor (ER)‐positive breast cancer cell line, and antagonist/agonist transcriptional activities were determined. Docking studies and competition studies of triphenylmethanes and radiolabeled estradiol determined that these compounds do not bind the ER, indicating that triphenylmethane‐induced changes in proliferative and transcriptional activities differ from conventional mechanisms of action triggered by other selective ER modulators.
Type of Medium:
Online Resource
ISSN:
1860-7179
,
1860-7187
DOI:
10.1002/cmdc.201500148
Language:
English
Publisher:
Wiley
Publication Date:
2015
detail.hit.zdb_id:
2209649-8
SSG:
15,3
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