In:
ChemBioChem, Wiley, Vol. 4, No. 11 ( 2003-11-07), p. 1216-1221
Abstract:
Annonaceous acetogenins are a family of natural products with antitumor activities. The polyether mimic AA005 has been synthesized. The cytotoxic mechanism of AA005 was investigated. It was found that AA005 can induce the cell death of gastric tumor cells. Most AA005‐induced cell death is due to necrosis but partial and p53‐independent apoptosis is also detected. An expanded study with gastric tumor cells and a cell‐free system indicates that AA005 affects NADH:ubiquinone oxidoreductase (complex I; NADH=nicotinamide adenine dinucleotide, reduced form) in the mitochondrial electron transport system. These results show for the first time that the polyether mimic AA005 acts on the same biological target as the natural annonaceous acetogenins.
Type of Medium:
Online Resource
ISSN:
1439-4227
,
1439-7633
DOI:
10.1002/cbic.200300677
Language:
English
Publisher:
Wiley
Publication Date:
2003
detail.hit.zdb_id:
2020469-3
SSG:
12
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