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  • 1
    Online Resource
    Online Resource
    Congenital muscular dystrophies in China
    Wiley ; 2019
    In:  Clinical Genetics Vol. 96, No. 3 ( 2019-09), p. 207-215
    Details
    In: Clinical Genetics, Wiley, Vol. 96, No. 3 ( 2019-09), p. 207-215
    Abstract: Congenital muscular dystrophies (CMDs) are clinically and genetically heterogeneous conditions. We launched a nationwide study to determine the frequency of CMD in the Chinese population and assess the status of diagnosis and disease management for CMD in China. Cases were chosen from databases in 34 tertiary academic hospitals from 29 first‐level administrative divisions (provinces, municipalities, autonomous regions, and special administrative regions), and medical records were reviewed to confirm the diagnoses. The study included 409 patients, of those patients who consented to genetic testing (n = 340), mutations were identified in 286 of them. The most common forms identified were LAMA2 ‐related CMD (36.4%), followed by COL6‐related CMD (23.2%) and α‐dystroglycanopathy (21.0%). The forms of CMD related to mutations in LMNA and SEPN1 were less frequent (12.5% and 2.4%, respectively). We also recorded a significant difference in the diagnostic capabilities and disease management of CMD, with this being relatively backward in research centers from less developed regions. We provide, for the first time, comprehensive epidemiologic information of CMD in a large cohort of Chinese people. To our knowledge, this is the largest sample size of its kind so far highlighting the prevalence of CMD in China.
    Type of Medium: Online Resource
    ISSN: 0009-9163 , 1399-0004
    URL: Issue
    URL: Article
    DOI: 10.1111/cge.v96.3
    DOI: 10.1111/cge.13560
    RVK:
    WA 15000
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2004581-5
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  • 2
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    Inhalable nanocatchers for SARS-CoV-2 inhibition
    Proceedings of the National Academy of Sciences ; 2021
    In:  Proceedings of the National Academy of Sciences Vol. 118, No. 29 ( 2021-07-20)
    Details
    In: Proceedings of the National Academy of Sciences, Proceedings of the National Academy of Sciences, Vol. 118, No. 29 ( 2021-07-20)
    Abstract: The global coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome (SARS)–like coronavirus (SARS-CoV-2), presents an urgent health crisis. More recently, an increasing number of mutated strains of SARS-CoV-2 have been identified globally. Such mutations, especially those on the spike glycoprotein to render its higher binding affinity to human angiotensin-converting enzyme II (hACE2) receptors, not only resulted in higher transmission of SARS-CoV-2 but also raised serious concerns regarding the efficacies of vaccines against mutated viruses. Since ACE2 is the virus-binding protein on human cells regardless of viral mutations, we design hACE2-containing nanocatchers (NCs) as the competitor with host cells for virus binding to protect cells from SARS-CoV-2 infection. The hACE2-containing NCs, derived from the cellular membrane of genetically engineered cells stably expressing hACE2, exhibited excellent neutralization ability against pseudoviruses of both wild-type SARS-CoV-2 and the D614G variant. To prevent SARS-CoV-2 infections in the lung, the most vulnerable organ for COVID-19, we develop an inhalable formulation by mixing hACE2-containing NCs with mucoadhesive excipient hyaluronic acid, the latter of which could significantly prolong the retention of NCs in the lung after inhalation. Excitingly, inhalation of our formulation could lead to potent pseudovirus inhibition ability in hACE2-expressing mouse model, without imposing any appreciable side effects. Importantly, our inhalable hACE2-containing NCs in the lyophilized formulation would allow long-term storage, facilitating their future clinical use. Thus, this work may provide an alternative tactic to inhibit SARS-CoV-2 infections even with different mutations, exhibiting great potential for treatment of the ongoing COVID-19 epidemic.
    Type of Medium: Online Resource
    ISSN: 0027-8424 , 1091-6490
    URL: Article
    DOI: 10.1073/pnas.2102957118
    RVK:
    TA 1000
    RVK:
    WA 15000
    Language: English
    Publisher: Proceedings of the National Academy of Sciences
    Publication Date: 2021
    detail.hit.zdb_id: 209104-5
    detail.hit.zdb_id: 1461794-8
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  • 3
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    Effects of community structure on precipitation‐use efficiency of grasslands in northern Tibet
    Wiley ; 2017
    In:  Journal of Vegetation Science Vol. 28, No. 2 ( 2017-03), p. 281-290
    Details
    In: Journal of Vegetation Science, Wiley, Vol. 28, No. 2 ( 2017-03), p. 281-290
    Abstract: (1) What are the primary factors determining the precipitation‐use efficiency ( PUE ) in northern Tibet; (2) how does PUE respond to the gradients of biotic and abiotic factors; and (3) how do the composition and structure of plant functional groups ( PFG s) affect PUE ? Location Northern Tibet, China. Methods A community survey of species composition, cover and above‐ground net primary productivity ( ANPP ) was conducted within 1 m × 1 m plots in 62 slightly disturbed sites. The effects of community features (total cover, cover of PFG s and species richness) and environmental factors [mean annual precipitation ( MAP ), mean annual temperature, surface soil bulk density, pH and C and N content] on PUE were identified through Pearson's correlation analyses, hierarchical partitioning and ordinary regressions. Results Along the precipitation gradient, ANPP and PUE increased exponentially. Among the community features, total cover and cover of PFG s, including forbs and sedges, were the primary factors that determined PUE . The three cover variables, together with species richness, positively affected PUE and accounted for 47.6% of the total variation in PUE . Among the environmental factors, MAP , surface soil pH and N content were the most significantly related to PUE and accounted for 29.9% of the total contribution. Conclusion Communities with high cover, species richness and nutrient content, but low soil bulk density, presented the highest PUE . At a regional scale, PUE depended mainly on plant cover, especially the cover of PFG s, namely, forbs and sedges. Environmental factors, including MAP and surface soil N and C content, positively affected PUE , whereas soil pH and bulk density negatively affected PUE . Our results highlight the importance of considering community structure to understand PUE variations in natural alpine grasslands.
    Type of Medium: Online Resource
    ISSN: 1100-9233 , 1654-1103
    URL: Issue
    URL: Article
    DOI: 10.1111/jvs.2017.28.issue-2
    DOI: 10.1111/jvs.12484
    RVK:
    WA 15000
    Language: English
    Publisher: Wiley
    Publication Date: 2017
    detail.hit.zdb_id: 2047714-4
    detail.hit.zdb_id: 1053769-7
    SSG: 12
    SSG: 23
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  • 4
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    Below‐ground competition drives the self‐thinning process of Stipa purpurea populations in northern T ibet
    Wiley ; 2015
    In:  Journal of Vegetation Science Vol. 26, No. 1 ( 2015-01), p. 166-174
    Details
    In: Journal of Vegetation Science, Wiley, Vol. 26, No. 1 ( 2015-01), p. 166-174
    Abstract: Above‐ground, below‐ground and individual mass–density relationships for perennial herbs were examined along a natural precipitation gradient in northern Tibet. We asked: (1) how do the self‐thinning exponents respond to variation in precipitation; and (2) what mechanisms drive the observed population self‐thinning? Location The alpine grassland of northern Tibet. Methods Forty‐seven fenced sites along a precipitation gradient were established and surveyed in 2011 and 2012. Data (geographic coordinates, elevation, and vegetation information) were collected for Stipa purpurea populations at each site. Population self‐thinning exponents were estimated using reduced major axis regression. Results The self‐thinning exponents for below‐ground (−1.27, −0.47) and individual biomass (−1.26, −0.46) increased with increasing mean annual precipitation, but those for above‐ground biomass decreased with precipitation (0.18, −0.25). Soil resources (moisture and nutrients) are a more important constraining factor for below‐ground components than light is for above‐ground components. Root competition for below‐ground resources dominated in S .  purpurea population self‐thinning. The driving force of density regulation changed from above‐ground competition to below‐ground competition with increased drought stress. Our results indicate that an increased root/shoot ratio was linked to enhanced below‐ground competition and weakened above‐ground competition. Our study further confirmed the hypothesis that plant populations in different environments exhibit different biomass allocation patterns, which, in turn, leads to different biomass–density relationships. Conclusions Our study revealed the mechanisms of population self‐thinning for perennial herbs in the extreme environment of northern Tibet, where below‐ground processes play a critical role in regulating population self‐thinning. Our study also advances understanding of the interactions between above‐ and below‐ground processes, providing baseline knowledge useful for local grassland management.
    Type of Medium: Online Resource
    ISSN: 1100-9233 , 1654-1103
    URL: Issue
    URL: Article
    DOI: 10.1111/jvs.2015.26.issue-1
    DOI: 10.1111/jvs.12207
    RVK:
    WA 15000
    Language: English
    Publisher: Wiley
    Publication Date: 2015
    detail.hit.zdb_id: 2047714-4
    detail.hit.zdb_id: 1053769-7
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  • 5
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    Metamorphism-facilitated faulting in deforming orthopyroxene: Implications for global intermediate-depth seismicity
    Proceedings of the National Academy of Sciences ; 2022
    In:  Proceedings of the National Academy of Sciences Vol. 119, No. 11 ( 2022-03-15)
    Details
    In: Proceedings of the National Academy of Sciences, Proceedings of the National Academy of Sciences, Vol. 119, No. 11 ( 2022-03-15)
    Abstract: Intermediate-depth earthquakes that occur between ∼60- and 300-km depths in subducted oceanic slabs often form a double band of seismicity. The upper band of seismicity is predominantly within the basaltic crust and is thought to be facilitated by processes related to dehydration reactions. More controversial is the faulting mechanism of the lower band of seismicity (LBS), located within the subducted mantle lithosphere, which consists primarily of olivine and orthopyroxene (Opx). High-pressure petrological studies have shown that as the oceanic lithosphere subducts to below 60 to 70 km in depth, the Opx component undergoes an exothermic metamorphic reaction characterized by continuous garnet exsolution to depths of ∼250 km. Here, we simulate the mechanical behavior of syn-deformational metamorphosing Opx in oceanic lithosphere using controlled deformation experiments combined with acoustic emission detection. We show that deforming Opx under the pressure and temperature conditions corresponding to those of LBS fail consistently by macroscopic faulting, accompanied by numerous acoustic emission events, which are laboratory analogs of earthquakes. Microstructural analysis shows that syn-deformational metamorphism proceeds by garnet exsolution both within Opx grains and along grain boundaries. Ultrafine-grained reaction product (grain size as small as 50 nm) facilitates strain localization and weakening, promoting slip instability. An examination of thermal structures in nine subduction zones shows that temperature conditions in these LBSs are consistent with the kinetic onset of brittle behavior observed in the laboratory, considering the tradeoff between onset temperature and strain rate. These results suggest that metamorphosing Opx likely plays an important role in intraslab earthquake processes.
    Type of Medium: Online Resource
    ISSN: 0027-8424 , 1091-6490
    URL: Article
    DOI: 10.1073/pnas.2112386119
    RVK:
    TA 1000
    RVK:
    WA 15000
    Language: English
    Publisher: Proceedings of the National Academy of Sciences
    Publication Date: 2022
    detail.hit.zdb_id: 209104-5
    detail.hit.zdb_id: 1461794-8
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  • 6
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    Integration of sequence-similarity and functional association information can overcome intrinsic problems in orthology mapping across bacterial genomes
    Oxford University Press (OUP) ; 2011
    In:  Nucleic Acids Research Vol. 39, No. 22 ( 2011-12-01), p. e150-e150
    Details
    In: Nucleic Acids Research, Oxford University Press (OUP), Vol. 39, No. 22 ( 2011-12-01), p. e150-e150
    Type of Medium: Online Resource
    ISSN: 1362-4962 , 0305-1048
    URL: Article
    DOI: 10.1093/nar/gkr766
    RVK:
    WA 15000
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2011
    detail.hit.zdb_id: 1472175-2
    SSG: 12
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  • 7
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    Identification and characterization of OGG1 mutations in patients with Alzheimer's disease
    Oxford University Press (OUP) ; 2007
    In:  Nucleic Acids Research Vol. 35, No. 8 ( 2007-04-01), p. 2759-2766
    Details
    In: Nucleic Acids Research, Oxford University Press (OUP), Vol. 35, No. 8 ( 2007-04-01), p. 2759-2766
    Type of Medium: Online Resource
    ISSN: 0305-1048 , 1362-4962
    URL: Article
    DOI: 10.1093/nar/gkm189
    RVK:
    WA 15000
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2007
    detail.hit.zdb_id: 1472175-2
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  • 8
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    Biosynthesis of selenium nanoparticles and effects of selenite, selenate, and selenomethionine on cell growth and morphology in Rahnella aquatilis HX2
    Springer Science and Business Media LLC ; 2018
    In:  Applied Microbiology and Biotechnology Vol. 102, No. 14 ( 2018-7), p. 6191-6205
    Details
    In: Applied Microbiology and Biotechnology, Springer Science and Business Media LLC, Vol. 102, No. 14 ( 2018-7), p. 6191-6205
    Type of Medium: Online Resource
    ISSN: 0175-7598 , 1432-0614
    URL: Article
    DOI: 10.1007/s00253-018-9060-z
    RVK:
    WA 15000
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2018
    detail.hit.zdb_id: 1464336-4
    SSG: 12
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  • 9
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    Underpotential lithium plating on graphite anodes caused by temperature heterogeneity
    Proceedings of the National Academy of Sciences ; 2020
    In:  Proceedings of the National Academy of Sciences Vol. 117, No. 47 ( 2020-11-24), p. 29453-29461
    Details
    In: Proceedings of the National Academy of Sciences, Proceedings of the National Academy of Sciences, Vol. 117, No. 47 ( 2020-11-24), p. 29453-29461
    Abstract: Rechargeability and operational safety of commercial lithium (Li)-ion batteries demand further improvement. Plating of metallic Li on graphite anodes is a critical reason for Li-ion battery capacity decay and short circuit. It is generally believed that Li plating is caused by the slow kinetics of graphite intercalation, but in this paper, we demonstrate that thermodynamics also serves a crucial role. We show that a nonuniform temperature distribution within the battery can make local plating of Li above 0 V vs. Li 0 /Li + (room temperature) thermodynamically favorable. This phenomenon is caused by temperature-dependent shifts of the equilibrium potential of Li 0 /Li + . Supported by simulation results, we confirm the likelihood of this failure mechanism during commercial Li-ion battery operation, including both slow and fast charging conditions. This work furthers the understanding of nonuniform Li plating and will inspire future studies to prolong the cycling lifetime of Li-ion batteries.
    Type of Medium: Online Resource
    ISSN: 0027-8424 , 1091-6490
    URL: Article
    DOI: 10.1073/pnas.2009221117
    RVK:
    TA 1000
    RVK:
    WA 15000
    Language: English
    Publisher: Proceedings of the National Academy of Sciences
    Publication Date: 2020
    detail.hit.zdb_id: 209104-5
    detail.hit.zdb_id: 1461794-8
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  • 10
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    The small RNA chaperone Hfq is a critical regulator for bacterial biosynthesis of selenium nanoparticles and motility in Rahnella aquatilis
    Springer Science and Business Media LLC ; 2020
    In:  Applied Microbiology and Biotechnology Vol. 104, No. 4 ( 2020-02), p. 1721-1735
    Details
    In: Applied Microbiology and Biotechnology, Springer Science and Business Media LLC, Vol. 104, No. 4 ( 2020-02), p. 1721-1735
    Type of Medium: Online Resource
    ISSN: 0175-7598 , 1432-0614
    URL: Article
    DOI: 10.1007/s00253-019-10231-4
    RVK:
    WA 15000
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2020
    detail.hit.zdb_id: 1464336-4
    SSG: 12
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