In:
European Journal of Endocrinology, Oxford University Press (OUP), Vol. 169, No. 1 ( 2013-07), p. 127-132
Abstract:
Excess GH causes insulin resistance and impaired glucose metabolism. The objective of this study was to clarify the prevalence of ketoacidosis as the initial presenting symptom of acromegaly. Design and methods Data were collected from 860 patients with acromegaly who underwent pituitary surgery at Toranomon Hospital over the last 32 years, between 1980 and 2011. Results Nine cases had ketoacidosis before being diagnosed with acromegaly, including seven males and two females with a mean± s.d. age of 38.8±14.2 years. Serum GH and IGF1 levels were 155±203 ng/ml and 9.86±0.68 SDS before pituitary surgery and 3.6±1.7 ng/ml and 3.72±3.40 SDS after surgery respectively. The maximum tumor diameter was 28.2±11.6 mm (ranging from 15 to 47 mm, n =8). None of the patients were diagnosed with diabetes mellitus (DM) nor were they positive for antibodies related to type 1 DM. A possible precipitating factor for ketoacidosis in six cases was excessive ingestion of sugar-containing soft drinks. All the cases had invasive pituitary adenomas. After pituitary surgery, plasma glucose levels were under control without requiring insulin in all cases. Furthermore, six patients did not need oral hypoglycemic agents. Conclusions Approximately 1% of patients with acromegaly presented with diabetic ketoacidosis as their first clinical condition.
Type of Medium:
Online Resource
ISSN:
0804-4643
,
1479-683X
Language:
Unknown
Publisher:
Oxford University Press (OUP)
Publication Date:
2013
detail.hit.zdb_id:
1485160-X
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