In:
FEBS Letters, Wiley, Vol. 590, No. 9 ( 2016-05), p. 1354-1364
Abstract:
Intestinal barrier dysfunction is a significant clinical problem, which develops in a variety of acute or chronic pathological conditions. In a previous study, we found that microRNA‐874 (miR‐874) suppresses aquaporin‐3 ( AQP 3) expression, which contributes significantly to intestinal barrier dysfunction. Recently, a new regulatory circuit was identified in which RNA can crosstalk with each other by competing for shared miRNA. Here, we show that the human long noncoding RNA (lnc RNA ) H19 may function as a competing endogenous RNA (ce RNA ) to regulate the expression of AQP 3 through competition for miR‐874, thus playing a significant role in maintaining intestinal barrier function.
Type of Medium:
Online Resource
ISSN:
0014-5793
,
1873-3468
DOI:
10.1002/1873-3468.12171
Language:
English
Publisher:
Wiley
Publication Date:
2016
detail.hit.zdb_id:
1460391-3
SSG:
12
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