In:
Journal of Applied Physiology, American Physiological Society, Vol. 94, No. 6 ( 2003-06-01), p. 2384-2390
Abstract:
Exhaled nitric oxide (Fe NO ) measurements provide a noninvasive approach to the evaluation of airway inflammation. Flow-independent NO exchange parameters [airway NO transfer factor (D NO ) and airway wall NO concentration (Cw NO )] can be estimated from Fe NO measurements at low flows and may elucidate mechanisms of disturbances in NO exchange. We measured Fe NO in sedated infants by using an adaptation of a raised lung volume rapid thoracic compression technique that creates forced expiration through a mass-flow controller that lasts 5–10 s, at a constant preset flow. We measured Fe NO at expired flows of 50, 25, and 15 ml/s in five healthy infants (7–31 mo). Median Fe NO increased [24, 40, and 60 parts per billion (ppb)] with decreasing expiratory flows (50, 25, and 15 ml/s). Group median (range) for D NO and Cw NO were 12.7 (3.2–37) × 10 −3 nl · s −1 · ppb −1 and 108.9 (49–385) ppb, respectively, similar to values reported in healthy adults. Exhaled NO is flow dependent; flow-independent parameters of exhaled NO kinetics can be assessed in infants and are similar to values described in adults.
Type of Medium:
Online Resource
ISSN:
8750-7587
,
1522-1601
DOI:
10.1152/japplphysiol.00758.2002
Language:
English
Publisher:
American Physiological Society
Publication Date:
2003
detail.hit.zdb_id:
1404365-8
SSG:
12
SSG:
31
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