In:
FEBS Letters, Wiley, Vol. 470, No. 1 ( 2000-03-17), p. 70-76
Abstract:
C‐terminal kinesin motor proteins, such as the Drosophila NCD and yeast KAR3, are involved in chromosomal segregation. Previously we have described two orthologs of NCD in Caenorhabditis elegans , KLP‐3 and KLP‐17, which also participate in chromosome movement. Here we report cDNA cloning of klp‐15 and klp‐16 , and the expression pattern of the genes encoding C‐terminal motor kinesins including klp‐15 and klp‐16 . Interestingly KLP‐15 and KLP‐16 form a unique class of C‐terminal kinesins, distinct from the previously known C‐terminal motors in other organisms. Using in situ hybridization and RNA interference assay, we show that although all of these motors mediate chromosome segregation, they do so in a combination of unique and overlapping manners, suggesting a complex hierarchy of kinesin motor function in metazoans.
Type of Medium:
Online Resource
ISSN:
0014-5793
,
1873-3468
DOI:
10.1016/S0014-5793(00)01258-8
Language:
English
Publisher:
Wiley
Publication Date:
2000
detail.hit.zdb_id:
1460391-3
SSG:
12
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